Walker RT - Search Results

1

Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.

Baba M, Shigeta S, Yuasa S, Takashima H, Sekiya K, Ubasawa M, Tanaka H, Miyasaka T, Walker RT, De Clercq E. Baba M, et al. Among authors: walker rt. Antimicrob Agents Chemother. 1994 Apr;38(4):688-92. doi: 10.1128/AAC.38.4.688. Antimicrob Agents Chemother. 1994. PMID: 7518216 Free PMC article.

2

Highly potent and selective inhibition of HIV-1 replication by 6-phenylthiouracil derivatives.

Baba M, Shigeta S, Tanaka H, Miyasaka T, Ubasawa M, Umezu K, Walker RT, Pauwels R, De Clercq E. Baba M, et al. Among authors: walker rt. Antiviral Res. 1992 Apr;17(4):245-64. doi: 10.1016/0166-3542(92)90021-v. Antiviral Res. 1992. PMID: 1379423 Review. No abstract available.

3

Synergistic inhibition of human immunodeficiency virus type 1 (HIV-1) replication in vitro by 1-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT) and recombinant alpha interferon.

Ito M, Baba M, Shigeta S, De Clercq E, Walker RT, Tanaka H, Miyasaka T. Ito M, et al. Among authors: walker rt. Antiviral Res. 1991 May;15(4):323-30. doi: 10.1016/0166-3542(91)90013-h. Antiviral Res. 1991. PMID: 1683214

4

Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives.

Baba M, De Clercq E, Tanaka H, Ubasawa M, Takashima H, Sekiya K, Nitta I, Umezu K, Walker RT, Mori S, et al. Baba M, et al. Among authors: walker rt. Mol Pharmacol. 1991 Jun;39(6):805-10. Mol Pharmacol. 1991. PMID: 1711148

5

Synergistic inhibition of human immunodeficiency virus type 1 replication by 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil (E-EPU) and azidothymidine in vitro.

Baba M, Ito M, Shigeta S, Tanaka H, Miyasaka T, Ubasawa M, Umezu K, Walker RT, De Clercq E. Baba M, et al. Among authors: walker rt. Antimicrob Agents Chemother. 1991 Jul;35(7):1430-3. doi: 10.1128/AAC.35.7.1430. Antimicrob Agents Chemother. 1991. PMID: 1929304 Free PMC article.

6

Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding.

Baba M, Yuasa S, Niwa T, Yamamoto M, Yabuuchi S, Takashima H, Ubasawa M, Tanaka H, Miyasaka T, Walker RT, et al. Baba M, et al. Among authors: walker rt. Biochem Pharmacol. 1993 Jun 22;45(12):2507-12. doi: 10.1016/0006-2952(93)90232-l. Biochem Pharmacol. 1993. PMID: 8328988

7

Allosteric inhibitors against HIV-1 reverse transcriptase: design and synthesis of MKC-442 analogues having an omega-functionalized acyclic structure.

Tanaka H, Walker RT, Hopkins AL, Ren J, Jones EY, Fujimoto K, Hayashi M, Miyasaka T, Baba M, Stammers DK, Stuart DI. Tanaka H, et al. Among authors: walker rt. Antivir Chem Chemother. 1998 Jul;9(4):325-32. Antivir Chem Chemother. 1998. PMID: 9875411

8

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1992 Dec 11;35(25):4713-9. doi: 10.1021/jm00103a009. J Med Chem. 1992. PMID: 1469700

9

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1992 Jan 24;35(2):337-45. doi: 10.1021/jm00080a020. J Med Chem. 1992. PMID: 1732552

10

Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

Tanaka H, Baba M, Ubasawa M, Takashima H, Sekiya K, Nitta I, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: walker rt. J Med Chem. 1991 Apr;34(4):1394-9. doi: 10.1021/jm00108a023. J Med Chem. 1991. PMID: 2016715

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