Takashima H - Search Results

1

Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro.

Baba M, Shigeta S, Yuasa S, Takashima H, Sekiya K, Ubasawa M, Tanaka H, Miyasaka T, Walker RT, De Clercq E. Baba M, et al. Among authors: takashima h. Antimicrob Agents Chemother. 1994 Apr;38(4):688-92. doi: 10.1128/AAC.38.4.688. Antimicrob Agents Chemother. 1994. PMID: 7518216 Free PMC article.

2

Potent and selective inhibition of human immunodeficiency virus type 1 (HIV-1) by 5-ethyl-6-phenylthiouracil derivatives through their interaction with the HIV-1 reverse transcriptase.

Baba M, De Clercq E, Tanaka H, Ubasawa M, Takashima H, Sekiya K, Nitta I, Umezu K, Nakashima H, Mori S, et al. Baba M, et al. Among authors: takashima h. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2356-60. doi: 10.1073/pnas.88.6.2356. Proc Natl Acad Sci U S A. 1991. PMID: 1706522 Free PMC article.

3

Highly potent and selective inhibition of human immunodeficiency virus type 1 by a novel series of 6-substituted acyclouridine derivatives.

Baba M, De Clercq E, Tanaka H, Ubasawa M, Takashima H, Sekiya K, Nitta I, Umezu K, Walker RT, Mori S, et al. Baba M, et al. Among authors: takashima h. Mol Pharmacol. 1991 Jun;39(6):805-10. Mol Pharmacol. 1991. PMID: 1711148

4

Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives.

Baba M, De Clercq E, Iida S, Tanaka H, Nitta I, Ubasawa M, Takashima H, Sekiya K, Umezu K, Nakashima H, et al. Baba M, et al. Among authors: takashima h. Antimicrob Agents Chemother. 1990 Dec;34(12):2358-63. doi: 10.1128/AAC.34.12.2358. Antimicrob Agents Chemother. 1990. PMID: 2088190 Free PMC article.

5

Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.

Yuasa S, Sadakata Y, Takashima H, Sekiya K, Inouye N, Ubasawa M, Baba M. Yuasa S, et al. Among authors: takashima h. Mol Pharmacol. 1993 Oct;44(4):895-900. Mol Pharmacol. 1993. PMID: 7694070

6

Effect of human serum on the in vitro anti-HIV-1 activity of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) derivatives as related to their lipophilicity and serum protein binding.

Baba M, Yuasa S, Niwa T, Yamamoto M, Yabuuchi S, Takashima H, Ubasawa M, Tanaka H, Miyasaka T, Walker RT, et al. Baba M, et al. Among authors: takashima h. Biochem Pharmacol. 1993 Jun 22;45(12):2507-12. doi: 10.1016/0006-2952(93)90232-l. Biochem Pharmacol. 1993. PMID: 8328988

7

Synthesis and antiviral activity of deoxy analogs of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) as potent and selective anti-HIV-1 agents.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: takashima h. J Med Chem. 1992 Dec 11;35(25):4713-9. doi: 10.1021/jm00103a009. J Med Chem. 1992. PMID: 1469700

8

Structure-activity relationships of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine analogues: effect of substitutions at the C-6 phenyl ring and at the C-5 position on anti-HIV-1 activity.

Tanaka H, Takashima H, Ubasawa M, Sekiya K, Nitta I, Baba M, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: takashima h. J Med Chem. 1992 Jan 24;35(2):337-45. doi: 10.1021/jm00080a020. J Med Chem. 1992. PMID: 1732552

9

A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

Tanaka H, Baba M, Hayakawa H, Sakamaki T, Miyasaka T, Ubasawa M, Takashima H, Sekiya K, Nitta I, Shigeta S, et al. Tanaka H, et al. Among authors: takashima h. J Med Chem. 1991 Jan;34(1):349-57. doi: 10.1021/jm00105a055. J Med Chem. 1991. PMID: 1992136

10

Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT).

Tanaka H, Baba M, Ubasawa M, Takashima H, Sekiya K, Nitta I, Shigeta S, Walker RT, De Clercq E, Miyasaka T. Tanaka H, et al. Among authors: takashima h. J Med Chem. 1991 Apr;34(4):1394-9. doi: 10.1021/jm00108a023. J Med Chem. 1991. PMID: 2016715

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

909 results

Search Page

Filters