Hamilton AD - Search Results

1

Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors.

Kauffmann RC, Qian Y, Vogt A, Sebti SM, Hamilton AD, Carthew RW. Kauffmann RC, et al. Among authors: hamilton ad. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10919-23. doi: 10.1073/pnas.92.24.10919. Proc Natl Acad Sci U S A. 1995. PMID: 7479910 Free PMC article.

2

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.

Lerner EC, Qian Y, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: hamilton ad. J Biol Chem. 1995 Nov 10;270(45):26770-3. doi: 10.1074/jbc.270.45.26770. J Biol Chem. 1995. PMID: 7592913 Free article.

3

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: hamilton ad. J Biol Chem. 1995 Nov 10;270(45):26802-6. doi: 10.1074/jbc.270.45.26802. J Biol Chem. 1995. PMID: 7592920 Free article.

4

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

Sun J, Qian Y, Hamilton AD, Sebti SM. Sun J, et al. Among authors: hamilton ad. Cancer Res. 1995 Oct 1;55(19):4243-7. Cancer Res. 1995. PMID: 7671229

5

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.

Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: hamilton ad. J Biol Chem. 1995 Jan 13;270(2):660-4. doi: 10.1074/jbc.270.2.660. J Biol Chem. 1995. PMID: 7822292 Free article.

6

Potent inhibition of human tumor p21ras farnesyltransferase by A1A2-lacking p21ras CA1A2X peptidomimetics.

Nigam M, Seong CM, Qian Y, Hamilton AD, Sebti SM. Nigam M, et al. Among authors: hamilton ad. J Biol Chem. 1993 Oct 5;268(28):20695-8. J Biol Chem. 1993. PMID: 8407887 Free article.

7

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.

Qian Y, Vogt A, Sebti SM, Hamilton AD. Qian Y, et al. Among authors: hamilton ad. J Med Chem. 1996 Jan 5;39(1):217-23. doi: 10.1021/jm950414g. J Med Chem. 1996. PMID: 8568811

8

Farnesyltransferase as a target for anticancer drug design.

Qian Y, Sebti SM, Hamilton AD. Qian Y, et al. Among authors: hamilton ad. Biopolymers. 1997;43(1):25-41. doi: 10.1002/(SICI)1097-0282(1997)43:1<25::AID-BIP4>3.0.CO;2-2. Biopolymers. 1997. PMID: 9174410 Review.

9

Inhibition of Ras prenylation: a novel approach to cancer chemotherapy.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Pharmacol Ther. 1997;74(1):103-14. doi: 10.1016/s0163-7258(97)00014-4. Pharmacol Ther. 1997. PMID: 9336018 Review.

10

Burkitt lymphoma Daudi cells contain two distinct farnesyltransferases with different divalent cation requirements.

Vogt A, Sun J, Qian Y, Tan-Chiu E, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: hamilton ad. Biochemistry. 1995 Sep 26;34(38):12398-403. doi: 10.1021/bi00038a037. Biochemistry. 1995. PMID: 7547984

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