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A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.
Dalpiaz A, Bertolasi V, Borea PA, Nacci V, Fiorini I, Campiani G, Mennini T, Manzoni C, Novellino E, Greco G. Dalpiaz A, et al. Among authors: borea pa. J Med Chem. 1995 Nov 10;38(23):4730-8. doi: 10.1021/jm00023a013. J Med Chem. 1995. PMID: 7473601
Binding thermodynamics of adenosine A2a receptor ligands.
Borea PA, Dalpiaz A, Varani K, Guerra L, Gilli G. Borea PA, et al. Biochem Pharmacol. 1995 Feb 14;49(4):461-9. doi: 10.1016/0006-2952(94)00464-w. Biochem Pharmacol. 1995. PMID: 7532939
The results are compared with those already reported for the binding of the same compounds to rat brain minus striatum adenosine A1 receptors obtained by displacing [3H]CHA as A1 selective radioligand (Borea PA et al., Mol Neuropharmacol 2: 273-281, 1992). The compa …
The results are compared with those already reported for the binding of the same compounds to rat brain minus striatum adenosine A1 receptor …
336 results