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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8. doi: 10.1073/pnas.0402357101. Epub 2004 Jul 26.
Proc Natl Acad Sci U S A. 2004.
PMID: 15277684
Free PMC article.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Zhuang L, Wai JS, Embrey MW, Fisher TE, Egbertson MS, Payne LS, Guare JP Jr, Vacca JP, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Witmer MV, Moyer G, Schleif WA, Gabryelski LJ, Leonard YM, Lynch JJ Jr, Michelson SR, Young SD.
Zhuang L, et al. Among authors: guare jp jr.
J Med Chem. 2003 Feb 13;46(4):453-6. doi: 10.1021/jm025553u.
J Med Chem. 2003.
PMID: 12570367
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4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Wai JS, Egbertson MS, Payne LS, Fisher TE, Embrey MW, Tran LO, Melamed JY, Langford HM, Guare JP Jr, Zhuang L, Grey VE, Vacca JP, Holloway MK, Naylor-Olsen AM, Hazuda DJ, Felock PJ, Wolfe AL, Stillmock KA, Schleif WA, Gabryelski LJ, Young SD.
Wai JS, et al. Among authors: guare jp jr.
J Med Chem. 2000 Dec 28;43(26):4923-6. doi: 10.1021/jm000176b.
J Med Chem. 2000.
PMID: 11150161
No abstract available.
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Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.
Huff JR, Baldwin JJ, deSolms SJ, Guare JP Jr, Hunt CA, Randall WC, Sanders WS, Smith SJ, Vacca JP, Zrada MM.
Huff JR, et al. Among authors: guare jp jr.
J Med Chem. 1988 Mar;31(3):641-5. doi: 10.1021/jm00398a025.
J Med Chem. 1988.
PMID: 2831365
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Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Saari WS, Halczenko W, Huff JR, Guare JP Jr, Hunt CA, Randall WC, Lotti VJ, Yarbrough GG.
Saari WS, et al. Among authors: guare jp jr.
J Med Chem. 1984 Sep;27(9):1182-5. doi: 10.1021/jm00375a017.
J Med Chem. 1984.
PMID: 6088770
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Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.
Saari WS, Halczenko W, King SW, Huff JR, Guare JP Jr, Hunt CA, Randall WC, Anderson PS, Lotti VJ, Taylor DA, et al.
Saari WS, et al. Among authors: guare jp jr.
J Med Chem. 1983 Dec;26(12):1696-701. doi: 10.1021/jm00366a007.
J Med Chem. 1983.
PMID: 6139479
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