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Page 1
Altered mitochondrial unfolded protein response and protein quality control promote oxidative distress in down syndrome brain.
Lanzillotta S, Esteve D, Lanzillotta C, Tramutola A, Lloret A, Forte E, Pesce V, Picca A, Di Domenico F, Perluigi M, Barone E. Lanzillotta S, et al. Among authors: tramutola a. Free Radic Biol Med. 2025 Feb 1;227:80-93. doi: 10.1016/j.freeradbiomed.2024.11.043. Epub 2024 Nov 23. Free Radic Biol Med. 2025. PMID: 39586382 Free article.
Aging exacerbates oxidative stress and liver fibrosis in an animal model of Down Syndrome.
Giallongo S, Ferrigno J, Caltabiano R, Broggi G, Alanazi AM, Distefano A, Tropea E, Tramutola A, Perluigi M, Volti GL, Barone E, Barbagallo IA. Giallongo S, et al. Among authors: tramutola a. Aging (Albany NY). 2024 Jun 26;16(12):10203-10215. doi: 10.18632/aging.205970. Epub 2024 Jun 26. Aging (Albany NY). 2024. PMID: 38942607 Free PMC article.
Biliverdin Reductase-A integrates insulin signaling with mitochondrial metabolism through phosphorylation of GSK3β.
Lanzillotta C, Tramutola A, Lanzillotta S, Greco V, Pagnotta S, Sanchini C, Di Angelantonio S, Forte E, Rinaldo S, Paone A, Cutruzzolà F, Cimini FA, Barchetta I, Cavallo MG, Urbani A, Butterfield DA, Di Domenico F, Paul BD, Perluigi M, Duarte JMN, Barone E. Lanzillotta C, et al. Among authors: tramutola a. Redox Biol. 2024 Jul;73:103221. doi: 10.1016/j.redox.2024.103221. Epub 2024 Jun 1. Redox Biol. 2024. PMID: 38843768 Free PMC article.
Engineering memory with an extrinsically disordered kinase.
Ripoli C, Dagliyan O, Renna P, Pastore F, Paciello F, Sollazzo R, Rinaudo M, Battistoni M, Martini S, Tramutola A, Sattin A, Barone E, Saneyoshi T, Fellin T, Hayashi Y, Grassi C. Ripoli C, et al. Among authors: tramutola a. Sci Adv. 2023 Nov 17;9(46):eadh1110. doi: 10.1126/sciadv.adh1110. Epub 2023 Nov 15. Sci Adv. 2023. PMID: 37967196 Free PMC article.
Intranasal Administration of KYCCSRK Peptide Rescues Brain Insulin Signaling Activation and Reduces Alzheimer's Disease-like Neuropathology in a Mouse Model for Down Syndrome.
Tramutola A, Lanzillotta S, Aceto G, Pagnotta S, Ruffolo G, Cifelli P, Marini F, Ripoli C, Palma E, Grassi C, Di Domenico F, Perluigi M, Barone E. Tramutola A, et al. Antioxidants (Basel). 2023 Jan 2;12(1):111. doi: 10.3390/antiox12010111. Antioxidants (Basel). 2023. PMID: 36670973 Free PMC article.
CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down Syndrome.
Pagnotta S, Tramutola A, Barone E, Di Domenico F, Pittalà V, Salerno L, Folgiero V, Caforio M, Locatelli F, Petrini S, Butterfield DA, Perluigi M. Pagnotta S, et al. Among authors: tramutola a. Free Radic Biol Med. 2022 Apr;183:1-13. doi: 10.1016/j.freeradbiomed.2022.03.006. Epub 2022 Mar 11. Free Radic Biol Med. 2022. PMID: 35283228 Review.
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