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Page 1
Cryo-EM structure and regulation of human NAD kinase.
Praharaj PP, Li Y, Mary C, Soflaee MH, Ryu K, Kim D, Tran DH, Dey T, Tom HJ, Rion H, Gelin M, Lemoff A, Zacharias LG, Patricio JS, Mathews TP, Chen Z, Lionne C, Hoxhaj G, Labesse G. Praharaj PP, et al. Among authors: zacharias lg. Sci Adv. 2025 Jan 24;11(4):eads2664. doi: 10.1126/sciadv.ads2664. Epub 2025 Jan 24. Sci Adv. 2025. PMID: 39854463 Free PMC article.
In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors.
Pachnis P, Wu Z, Faubert B, Tasdogan A, Gu W, Shelton S, Solmonson A, Rao AD, Kaushik AK, Rogers TJ, Ubellacker JM, LaVigne CA, Yang C, Ko B, Ramesh V, Sudderth J, Zacharias LG, Martin-Sandoval MS, Do D, Mathews TP, Zhao Z, Mishra P, Morrison SJ, DeBerardinis RJ. Pachnis P, et al. Among authors: zacharias lg. Sci Adv. 2022 Sep 2;8(35):eabn9550. doi: 10.1126/sciadv.abn9550. Epub 2022 Aug 31. Sci Adv. 2022. PMID: 36044570 Free PMC article.
Metabolic inflexibility promotes mitochondrial health during liver regeneration.
Wang X, Menezes CJ, Jia Y, Xiao Y, Venigalla SSK, Cai F, Hsieh MH, Gu W, Du L, Sudderth J, Kim D, Shelton SD, Llamas CB, Lin YH, Zhu M, Merchant S, Bezwada D, Kelekar S, Zacharias LG, Mathews TP, Hoxhaj G, Wynn RM, Tambar UK, DeBerardinis RJ, Zhu H, Mishra P. Wang X, et al. Among authors: zacharias lg. Science. 2024 Jun 14;384(6701):eadj4301. doi: 10.1126/science.adj4301. Epub 2024 Jun 14. Science. 2024. PMID: 38870309 Free PMC article.
Electron transport chain inhibition increases cellular dependence on purine transport and salvage.
Wu Z, Bezwada D, Cai F, Harris RC, Ko B, Sondhi V, Pan C, Vu HS, Nguyen PT, Faubert B, Cai L, Chen H, Martin-Sandoval M, Do D, Gu W, Zhang Y, Zhang Y, Brooks B, Kelekar S, Zacharias LG, Oaxaca KC, Patricio JS, Mathews TP, Garcia-Bermudez J, Ni M, DeBerardinis RJ. Wu Z, et al. Among authors: zacharias lg. Cell Metab. 2024 Jul 2;36(7):1504-1520.e9. doi: 10.1016/j.cmet.2024.05.014. Epub 2024 Jun 13. Cell Metab. 2024. PMID: 38876105 Free PMC article.
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.
Kaushik AK, Tarangelo A, Boroughs LK, Ragavan M, Zhang Y, Wu CY, Li X, Ahumada K, Chiang JC, Tcheuyap VT, Saatchi F, Do QN, Yong C, Rosales T, Stevens C, Rao AD, Faubert B, Pachnis P, Zacharias LG, Vu H, Cai F, Mathews TP, Genovese G, Slusher BS, Kapur P, Sun X, Merritt M, Brugarolas J, DeBerardinis RJ. Kaushik AK, et al. Among authors: zacharias lg. Sci Adv. 2022 Dec 16;8(50):eabp8293. doi: 10.1126/sciadv.abp8293. Epub 2022 Dec 16. Sci Adv. 2022. PMID: 36525494 Free PMC article.
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples.
Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang MC, Pachnis P, Yang C, Kelekar S, Gu W, Brooks B, Ko B, Vu HS, Mathews TP, Zacharias LG, Martin-Sandoval M, Do D, Oaxaca KC, Jin ES, Margulis V, Malloy CR, Merritt ME, DeBerardinis RJ. Cai F, et al. Among authors: zacharias lg. Cell Metab. 2023 Oct 3;35(10):1830-1843.e5. doi: 10.1016/j.cmet.2023.07.013. Epub 2023 Aug 22. Cell Metab. 2023. PMID: 37611583 Free PMC article.
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases.
Parida PK, Marquez-Palencia M, Ghosh S, Khandelwal N, Kim K, Nair V, Liu XZ, Vu HS, Zacharias LG, Gonzalez-Ericsson PI, Sanders ME, Mobley BC, McDonald JG, Lemoff A, Peng Y, Lewis C, Vale G, Halberg N, Arteaga CL, Hanker AB, DeBerardinis RJ, Malladi S. Parida PK, et al. Among authors: zacharias lg. Nat Cancer. 2023 Jun;4(6):893-907. doi: 10.1038/s43018-023-00563-6. Epub 2023 May 29. Nat Cancer. 2023. PMID: 37248394 Free PMC article.
28 results