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445 results

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Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis.
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Bachoo RM, et al. Among authors: depinho ra. Cancer Cell. 2024 Dec 9;42(12):2124. doi: 10.1016/j.ccell.2024.11.007. Cancer Cell. 2024. PMID: 39663072 No abstract available.
Genetics and biology of pancreatic ductal adenocarcinoma.
Ying H, Kimmelman AC, Bardeesy N, Kalluri R, Maitra A, DePinho RA. Ying H, et al. Among authors: depinho ra. Genes Dev. 2025 Jan 7;39(1-2):36-63. doi: 10.1101/gad.351863.124. Genes Dev. 2025. PMID: 39510840 Review.
Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer.
Saito Y, Xiao Y, Yao J, Li Y, Liu W, Yuzhalin AE, Shyu YM, Li H, Yuan X, Li P, Zhang Q, Li Z, Wei Y, Yin X, Zhao J, Kariminia SM, Wu YC, Wang J, Yang J, Xia W, Sun Y, Jho EH, Chiao PJ, Hwang RF, Ying H, Wang H, Zhao Z, Maitra A, Hung MC, DePinho RA, Yu D. Saito Y, et al. Among authors: depinho ra. Cell Discov. 2024 Oct 29;10(1):109. doi: 10.1038/s41421-024-00720-w. Cell Discov. 2024. PMID: 39468013 Free PMC article.
Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers.
Takeda M, Theardy MS, Sorokin A, Coker O, Kanikarla P, Chen S, Yang Z, Nguyen P, Wei Y, Yao J, Wang X, Yan L, Jin Y, Cai Y, Paku M, Chen Z, Li KZ, Citron F, Tomihara H, Gao S, Deem AK, Zhao J, Wang H, Hanash S, DePinho RA, Maitra A, Draetta GF, Ying H, Kopetz S, Yao W. Takeda M, et al. Among authors: depinho ra. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606865. doi: 10.1101/2024.08.06.606865. bioRxiv. 2024. PMID: 39211217 Free PMC article. Preprint.
TERT activation targets DNA methylation and multiple aging hallmarks.
Shim HS, Iaconelli J, Shang X, Li J, Lan ZD, Jiang S, Nutsch K, Beyer BA, Lairson LL, Boutin AT, Bollong MJ, Schultz PG, DePinho RA. Shim HS, et al. Among authors: depinho ra. Cell. 2024 Jul 25;187(15):4030-4042.e13. doi: 10.1016/j.cell.2024.05.048. Epub 2024 Jun 21. Cell. 2024. PMID: 38908367
Telomere dysfunction alters intestinal stem cell dynamics to promote cancer.
LaBella KA, Hsu WH, Li J, Qi Y, Liu Y, Liu J, Wu CC, Liu Y, Song Z, Lin Y, Blecher JM, Jiang S, Shang X, Han J, Spring DJ, Zhang J, Xia Y, DePinho RA. LaBella KA, et al. Among authors: depinho ra. Dev Cell. 2024 Jun 3;59(11):1475-1486.e5. doi: 10.1016/j.devcel.2024.03.020. Epub 2024 Apr 3. Dev Cell. 2024. PMID: 38574731
Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer.
Bae SY, Ling HH, Chen Y, Chen H, Kumar D, Zhang J, Viny AD, DePinho RA, Giancotti FG. Bae SY, et al. Among authors: depinho ra. bioRxiv [Preprint]. 2024 Nov 1:2023.11.18.566087. doi: 10.1101/2023.11.18.566087. bioRxiv. 2024. PMID: 38014033 Free PMC article. Preprint.
KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer.
Wei Y, Liu M, Yen EY, Yao J, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Theady MS, Park J, Cai Y, Takeda M, Vasquez M, Zhou Y, Zhao H, Viale A, Wang H, Zhao D, DePinho RA, Yao W, Ying H. Wei Y, et al. Among authors: depinho ra. bioRxiv [Preprint]. 2023 Sep 23:2023.09.21.558891. doi: 10.1101/2023.09.21.558891. bioRxiv. 2023. PMID: 37790498 Free PMC article. Preprint.
445 results