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Page 1
YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates.
Bouzón-Arnáiz I, Rawat M, Coyle R, Feufack-Donfack LB, Ea M, Orban A, Popovici J, Román-Álamo L, Fallica AN, Domínguez-Asenjo B, Moreno J, Arce EM, Mallo-Abreu A, Muñoz-Torrero D, Lee MCS, Fernàndez-Busquets X. Bouzón-Arnáiz I, et al. Among authors: arce em. Sci Rep. 2025 Jan 23;15(1):2941. doi: 10.1038/s41598-025-85346-y. Sci Rep. 2025. PMID: 39848983 Free PMC article.
Leveraging the Aggregated Protein Dye YAT2150 for Malaria Chemotherapy.
Camarero-Hoyos C, Bouzón-Arnáiz I, Avalos-Padilla Y, Fallica AN, Román-Álamo L, Ramírez M, Portabella E, Cuspinera O, Currea-Ayala D, Orozco-Quer M, Ribera M, Siden-Kiamos I, Spanos L, Iglesias V, Crespo B, Viera S, Andreu D, Sulleiro E, Zarzuela F, Urtasun N, Pérez-Torras S, Pastor-Anglada M, Arce EM, Muñoz-Torrero D, Fernàndez-Busquets X. Camarero-Hoyos C, et al. Among authors: arce em. Pharmaceutics. 2024 Sep 30;16(10):1290. doi: 10.3390/pharmaceutics16101290. Pharmaceutics. 2024. PMID: 39458619 Free PMC article.
Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability.
Román-Álamo L, Avalos-Padilla Y, Bouzón-Arnáiz I, Iglesias V, Fernández-Lajo J, Monteiro JM, Rivas L, Fisa R, Riera C, Andreu D, Pintado-Grima C, Ventura S, Arce EM, Muñoz-Torrero D, Fernàndez-Busquets X. Román-Álamo L, et al. Among authors: arce em. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0112723. doi: 10.1128/aac.01127-23. Epub 2024 Feb 13. Antimicrob Agents Chemother. 2024. PMID: 38349159 Free PMC article.
From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects.
Pont C, Ginex T, Griñán-Ferré C, Scheiner M, Mattellone A, Martínez N, Arce EM, Soriano-Fernández Y, Naldi M, De Simone A, Barenys M, Gómez-Catalán J, Pérez B, Sabate R, Andrisano V, Loza MI, Brea J, Bartolini M, Bolognesi ML, Decker M, Pallàs M, Luque FJ, Muñoz-Torrero D. Pont C, et al. Among authors: arce em. Eur J Med Chem. 2021 Dec 5;225:113779. doi: 10.1016/j.ejmech.2021.113779. Epub 2021 Aug 16. Eur J Med Chem. 2021. PMID: 34418785 Free article.