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Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse.
Candela ME, Addison M, Aird R, Man TY, Cartwright JA, Ashmore-Harris C, Kilpatrick AM, Starkey Lewis PJ, Drape A, Barnett M, Mitchell D, McLean C, McGowan N, Turner M, Dear JW, Forbes SJ. Candela ME, et al. Among authors: forbes sj. NPJ Regen Med. 2025 Jan 22;10(1):5. doi: 10.1038/s41536-025-00393-3. NPJ Regen Med. 2025. PMID: 39843512 Free PMC article.
Macrophages as a Cell-Based Therapy for Liver Disease.
Starkey Lewis PJ, Moroni F, Forbes SJ. Starkey Lewis PJ, et al. Among authors: forbes sj. Semin Liver Dis. 2019 Nov;39(4):442-451. doi: 10.1055/s-0039-1688502. Epub 2019 Jun 26. Semin Liver Dis. 2019. PMID: 31242527 Free article. Review.
Alternatively activated macrophages promote resolution of necrosis following acute liver injury.
Starkey Lewis P, Campana L, Aleksieva N, Cartwright JA, Mackinnon A, O'Duibhir E, Kendall T, Vermeren M, Thomson A, Gadd V, Dwyer B, Aird R, Man TY, Rossi AG, Forrester L, Park BK, Forbes SJ. Starkey Lewis P, et al. Among authors: forbes sj. J Hepatol. 2020 Aug;73(2):349-360. doi: 10.1016/j.jhep.2020.02.031. Epub 2020 Mar 11. J Hepatol. 2020. PMID: 32169610 Free PMC article.
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK.
Humphries C, Addison M, Aithal G, Boyd J, Briody L, Campbell JDM, Candela ME, Clarke E, Coulson J, Downing-James N, Fontana RJ, Geddes A, Grahamslaw J, Grant A, Heye A, Hutchinson JA, Jones A, Mitchell F, Moore J, Riddell A, Rodriguez A, Thomas A, Tucker G, Walker K, Weir CJ, Woods R, Zahra S, Forbes SJ, Dear JW. Humphries C, et al. Among authors: forbes sj. BMJ Open. 2024 Dec 9;14(12):e089417. doi: 10.1136/bmjopen-2024-089417. BMJ Open. 2024. PMID: 39653576 Free PMC article.
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial.
Brennan PN, MacMillan M, Manship T, Moroni F, Glover A, Troland D, MacPherson I, Graham C, Aird R, Semple SIK, Morris DM, Fraser AR, Pass C, McGowan NWA, Turner ML, Manson L, Lachlan NJ, Dillon JF, Kilpatrick AM, Campbell JDM, Fallowfield JA, Forbes SJ. Brennan PN, et al. Among authors: forbes sj. Nat Med. 2025 Jan 10. doi: 10.1038/s41591-024-03406-8. Online ahead of print. Nat Med. 2025. PMID: 39794616
Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury.
Gadd VL, Ferreira-Gonzalez S, Man TY, Kilpatrick AM, Aird RE, Smith IP, Rodrigo-Torres D, Kurian D, Hallett JM, Ashmore-Harris C, Esser H, Ferreira MF, Macmillan MT, Lu WY, Forbes SJ. Gadd VL, et al. Among authors: forbes sj. J Hepatol. 2025 Jan 2:S0168-8278(24)02830-7. doi: 10.1016/j.jhep.2024.12.039. Online ahead of print. J Hepatol. 2025. PMID: 39755157 Free article.
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease.
Hallett JM, Ferreira-Gonzalez S, Man TY, Kilpatrick AM, Esser H, Thirlwell K, Macmillan MT, Rodrigo-Torres D, Dwyer BJ, Gadd VL, Ashmore-Harris C, Lu WY, Thomson JP, Jansen MA, O'Duibhir E, Starkey Lewis PJ, Campana L, Aird RE, Bate TSR, Fraser AR, Campbell JDM, Oniscu GC, Hay DC, Callanan A, Forbes SJ. Hallett JM, et al. Among authors: forbes sj. Cell Stem Cell. 2022 Mar 3;29(3):355-371.e10. doi: 10.1016/j.stem.2022.02.006. Cell Stem Cell. 2022. PMID: 35245467 Free PMC article.
194 results