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Cryopreserved human alternatively activated macrophages promote resolution of acetaminophen-induced liver injury in mouse.
Candela ME, Addison M, Aird R, Man TY, Cartwright JA, Ashmore-Harris C, Kilpatrick AM, Starkey Lewis PJ, Drape A, Barnett M, Mitchell D, McLean C, McGowan N, Turner M, Dear JW, Forbes SJ. Candela ME, et al. Among authors: dear jw. NPJ Regen Med. 2025 Jan 22;10(1):5. doi: 10.1038/s41536-025-00393-3. NPJ Regen Med. 2025. PMID: 39843512
BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity.
Marañón P, Isaza SC, Rey E, Rada P, García-García Y, Dear JW, García-Monzón C, Valverde ÁM, Egea J, González-Rodríguez Á. Marañón P, et al. Among authors: dear jw. Arch Toxicol. 2025 Jan 19. doi: 10.1007/s00204-024-03954-5. Online ahead of print. Arch Toxicol. 2025. PMID: 39827450
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK.
Humphries C, Addison M, Aithal G, Boyd J, Briody L, Campbell JDM, Candela ME, Clarke E, Coulson J, Downing-James N, Fontana RJ, Geddes A, Grahamslaw J, Grant A, Heye A, Hutchinson JA, Jones A, Mitchell F, Moore J, Riddell A, Rodriguez A, Thomas A, Tucker G, Walker K, Weir CJ, Woods R, Zahra S, Forbes SJ, Dear JW. Humphries C, et al. Among authors: dear jw. BMJ Open. 2024 Dec 9;14(12):e089417. doi: 10.1136/bmjopen-2024-089417. BMJ Open. 2024. PMID: 39653576 Free PMC article.
Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).
Scullion KM, MacIntyre IM, Sloan-Dennison S, Clark B, Fineran P, Mair J, Creasey D, Rathmell C, Faulds K, Graham D, Webb DJ, Dear JW. Scullion KM, et al. Among authors: dear jw. Toxicol Sci. 2024 May 28;199(2):203-209. doi: 10.1093/toxsci/kfae031. Toxicol Sci. 2024. PMID: 38521541 Free PMC article. Clinical Trial.
Candidate circulating microRNA biomarkers in dogs with chronic pancreatitis.
Armstrong SK, Hunter RW, Oosthyuzen W, Parys M, Gow AG, Schmitz SS, Dear JW, Mellanby RJ. Armstrong SK, et al. Among authors: dear jw. J Vet Intern Med. 2024 Mar-Apr;38(2):995-1004. doi: 10.1111/jvim.17009. Epub 2024 Feb 13. J Vet Intern Med. 2024. PMID: 38351718 Free PMC article.
151 results