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Functional classification of tauopathy strains reveals the role of protofilament core residues.
Vaquer-Alicea J, Manon VA, Bommareddy V, Kunach P, Gupta A, Monistrol J, Perez VA, Tran HT, Saez-Calveras N, Du S, Batra S, Stoddard D, White CL 3rd, Joachimiak LA, Shahmoradian SH, Diamond MI. Vaquer-Alicea J, et al. Among authors: joachimiak la. Sci Adv. 2025 Jan 24;11(4):eadp5978. doi: 10.1126/sciadv.adp5978. Epub 2025 Jan 22. Sci Adv. 2025. PMID: 39841851 Free PMC article.
Tau strains shape disease.
Vaquer-Alicea J, Diamond MI, Joachimiak LA. Vaquer-Alicea J, et al. Among authors: joachimiak la. Acta Neuropathol. 2021 Jul;142(1):57-71. doi: 10.1007/s00401-021-02301-7. Epub 2021 Apr 8. Acta Neuropathol. 2021. PMID: 33830330 Free PMC article. Review.
Network of hotspot interactions cluster tau amyloid folds.
Mullapudi V, Vaquer-Alicea J, Bommareddy V, Vega AR, Ryder BD, White CL 3rd, Diamond MI, Joachimiak LA. Mullapudi V, et al. Among authors: joachimiak la. Nat Commun. 2023 Feb 16;14(1):895. doi: 10.1038/s41467-023-36572-3. Nat Commun. 2023. PMID: 36797278 Free PMC article.
Seed-competent tau monomer initiates pathology in a tauopathy mouse model.
Mirbaha H, Chen D, Mullapudi V, Terpack SJ, White CL 3rd, Joachimiak LA, Diamond MI. Mirbaha H, et al. Among authors: joachimiak la. J Biol Chem. 2022 Aug;298(8):102163. doi: 10.1016/j.jbc.2022.102163. Epub 2022 Jun 22. J Biol Chem. 2022. PMID: 35750209 Free PMC article.
DnaJC7 specifically regulates tau seeding.
Perez VA, Sanders DW, Mendoza-Oliva A, Stopschinski BE, Mullapudi V, White CL, Joachimiak LA, Diamond MI. Perez VA, et al. Among authors: joachimiak la. Elife. 2023 Jun 30;12:e86936. doi: 10.7554/eLife.86936. Elife. 2023. PMID: 37387473 Free PMC article.
48 results