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Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype.
Petrova TV, Nykänen A, Norrmén C, Ivanov KI, Andersson LC, Haglund C, Puolakkainen P, Wempe F, von Melchner H, Gradwohl G, Vanharanta S, Aaltonen LA, Saharinen J, Gentile M, Clarke A, Taipale J, Oliver G, Alitalo K. Petrova TV, et al. Among authors: haglund c. Cancer Cell. 2008 May;13(5):407-19. doi: 10.1016/j.ccr.2008.02.020. Cancer Cell. 2008. PMID: 18455124 Free article.
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K. Wiener Z, et al. Among authors: haglund c. Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2229-36. doi: 10.1073/pnas.1406444111. Epub 2014 May 13. Proc Natl Acad Sci U S A. 2014. PMID: 24825889 Free PMC article.
15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
Thiel A, Ganesan A, Mrena J, Junnila S, Nykänen A, Hemmes A, Tai HH, Monni O, Kokkola A, Haglund C, Petrova TV, Ristimäki A. Thiel A, et al. Among authors: haglund c. Clin Cancer Res. 2009 Jul 15;15(14):4572-80. doi: 10.1158/1078-0432.CCR-08-2518. Epub 2009 Jul 7. Clin Cancer Res. 2009. PMID: 19584167
PROX1 is involved in progression of rectal neuroendocrine tumors, NETs.
Jernman J, Kallio P, Hagström J, Välimäki MJ, Haapasalo H, Alitalo K, Arola J, Haglund C. Jernman J, et al. Among authors: haglund c. Virchows Arch. 2015 Sep;467(3):279-84. doi: 10.1007/s00428-015-1795-7. Epub 2015 Jun 11. Virchows Arch. 2015. PMID: 26063416
High PROX1 expression in gastric cancer predicts better survival.
Laitinen A, Böckelman C, Hagström J, Kokkola A, Kallio P, Haglund C. Laitinen A, et al. Among authors: haglund c. PLoS One. 2017 Aug 30;12(8):e0183868. doi: 10.1371/journal.pone.0183868. eCollection 2017. PLoS One. 2017. PMID: 28854215 Free PMC article.
PROX1 is a transcriptional regulator of MMP14.
Gramolelli S, Cheng J, Martinez-Corral I, Vähä-Koskela M, Elbasani E, Kaivanto E, Rantanen V, Tuohinto K, Hautaniemi S, Bower M, Haglund C, Alitalo K, Mäkinen T, Petrova TV, Lehti K, Ojala PM. Gramolelli S, et al. Among authors: haglund c. Sci Rep. 2018 Jun 22;8(1):9531. doi: 10.1038/s41598-018-27739-w. Sci Rep. 2018. PMID: 29934628 Free PMC article.
515 results