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Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs.
Linthorst NA, Jongejan YK, Dirven RJ, Laan SNJ, Bierings R, Casari C, Cordfunke RA, Dahlman JE, Dolezal N, Drijfhout JW, Leebeek FWG, Ruhaak LR, Schrader Echeverri E, Voorberg J, van Vlijmen BJM, Denis CV, Eikenboom JCJ. Linthorst NA, et al. Among authors: dahlman je. Blood Adv. 2025 Jan 28;9(2):310-320. doi: 10.1182/bloodadvances.2024014601. Blood Adv. 2025. PMID: 39820471
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery.
Dobrowolski C, Paunovska K, Schrader Echeverri E, Loughrey D, Da Silva Sanchez AJ, Ni H, Hatit MZC, Lokugamage MP, Kuzminich Y, Peck HE, Santangelo PJ, Dahlman JE. Dobrowolski C, et al. Among authors: dahlman je. Nat Nanotechnol. 2022 Aug;17(8):871-879. doi: 10.1038/s41565-022-01146-9. Epub 2022 Jun 30. Nat Nanotechnol. 2022. PMID: 35768613
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo.
Radmand A, Lokugamage MP, Kim H, Dobrowolski C, Zenhausern R, Loughrey D, Huayamares SG, Hatit MZC, Ni H, Del Cid A, Da Silva Sanchez AJ, Paunovska K, Schrader Echeverri E, Shajii A, Peck H, Santangelo PJ, Dahlman JE. Radmand A, et al. Among authors: dahlman je. Nano Lett. 2023 Feb 8;23(3):993-1002. doi: 10.1021/acs.nanolett.2c04479. Epub 2023 Jan 26. Nano Lett. 2023. PMID: 36701517 Free PMC article.
Drug delivery systems for RNA therapeutics.
Paunovska K, Loughrey D, Dahlman JE. Paunovska K, et al. Among authors: dahlman je. Nat Rev Genet. 2022 May;23(5):265-280. doi: 10.1038/s41576-021-00439-4. Epub 2022 Jan 4. Nat Rev Genet. 2022. PMID: 34983972 Free PMC article. Review.
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery.
Da Silva Sanchez AJ, Dobrowolski C, Cristian A, Echeverri ES, Zhao K, Hatit MZC, Loughrey D, Paunovska K, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: dahlman je. Nano Lett. 2022 Jun 22;22(12):4822-4830. doi: 10.1021/acs.nanolett.2c01133. Epub 2022 Jun 7. Nano Lett. 2022. PMID: 35671473
Therapeutic RNA Delivery for COVID and Other Diseases.
Dobrowolski C, Paunovska K, Hatit MZC, Lokugamage MP, Dahlman JE. Dobrowolski C, et al. Among authors: dahlman je. Adv Healthc Mater. 2021 Aug;10(15):e2002022. doi: 10.1002/adhm.202002022. Epub 2021 Mar 4. Adv Healthc Mater. 2021. PMID: 33661555 Free PMC article. Review.
Substituting racemic ionizable lipids with stereopure ionizable lipids can increase mRNA delivery.
Da Silva Sanchez AJ, Zhao K, Huayamares SG, Hatit MZC, Lokugamage MP, Loughrey D, Dobrowolski C, Wang S, Kim H, Paunovska K, Kuzminich Y, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: dahlman je. J Control Release. 2023 Jan;353:270-277. doi: 10.1016/j.jconrel.2022.11.037. Epub 2022 Nov 30. J Control Release. 2023. PMID: 36423872 Free PMC article.
70 results