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Page 1
RECQL4 affects MHC class II-mediated signalling and favours an immune-evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melanoma.
Egea-Rodriguez S, Váraljai R, Nordmann TM, Lubis R, Philip M, Rambow F, Roesch A, Flaig M, Horn S, Stoll R, Zhao F, Paschen A, Klebl B, Hickson ID, Schadendorf D, Mann M, Helfrich I. Egea-Rodriguez S, et al. Among authors: helfrich i. Clin Transl Med. 2025 Jan;15(1):e70094. doi: 10.1002/ctm2.70094. Clin Transl Med. 2025. PMID: 39812592 Free PMC article.
Spatial proteomics reveals sirtuin 1 to be a determinant of T-cell infiltration in human melanoma.
Placke JM, Bottek J, Váraljai R, Shannan B, Scharfenberg S, Krisp C, Spangenberg P, Soun C, Siemes D, Borgards L, Hoffmann F, Zhao F, Paschen A, Schlueter H, von Eggeling F, Helfrich I, Rambow F, Ugurel S, Tasdogan A, Schadendorf D, Engel DR, Roesch A. Placke JM, et al. Among authors: helfrich i. Br J Dermatol. 2024 Dec 31:ljae433. doi: 10.1093/bjd/ljae433. Online ahead of print. Br J Dermatol. 2024. PMID: 39739311
Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1.
Wever MJA, Scommegna FR, Egea-Rodriguez S, Dehghani-Tafti S, Brandao-Neto J, Poisson JF, Helfrich I, Antson AA, Rodeschini V, Bax B, Roche D, Sanders CM. Wever MJA, et al. Among authors: helfrich i. Nucleic Acids Res. 2024 Nov 11;52(20):12616-12632. doi: 10.1093/nar/gkae897. Nucleic Acids Res. 2024. PMID: 39417423 Free PMC article.
T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels.
Messmer JM, Thommek C, Piechutta M, Venkataramani V, Wehner R, Westphal D, Schubert M, Mayer CD, Effern M, Berghoff AS, Hinze D, Helfrich I, Schadendorf D, Wick W, Hölzel M, Karreman MA, Winkler F. Messmer JM, et al. Among authors: helfrich i. Immunity. 2024 Nov 12;57(11):2688-2703.e11. doi: 10.1016/j.immuni.2024.09.003. Epub 2024 Oct 4. Immunity. 2024. PMID: 39368486 Free article.
ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis.
Cibir Z, Hassel J, Sonneck J, Kowitz L, Beer A, Kraus A, Hallekamp G, Rosenkranz M, Raffelberg P, Olfen S, Smilowski K, Burkard R, Helfrich I, Tuz AA, Singh V, Ghosh S, Sickmann A, Klebl AK, Eickhoff JE, Klebl B, Seidl K, Chen J, Grabmaier A, Viga R, Gunzer M. Cibir Z, et al. Among authors: helfrich i. Nat Commun. 2023 Dec 11;14(1):8103. doi: 10.1038/s41467-023-43765-3. Nat Commun. 2023. PMID: 38081825 Free PMC article.
Author Correction: Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma.
Váraljai R, Zimmer L, Al-Matary Y, Kaptein P, Albrecht LJ, Shannan B, Brase JC, Gusenleitner D, Amaral T, Wyss N, Utikal J, Flatz L, Rambow F, Reinhardt HC, Dick J, Engel DR, Horn S, Ugurel S, Sondermann W, Livingstone E, Sucker A, Paschen A, Zhao F, Placke JM, Klose JM, Fendler WP, Thommen DS, Helfrich I, Schadendorf D, Roesch A. Váraljai R, et al. Among authors: helfrich i. Nat Cancer. 2023 Sep;4(9):1395. doi: 10.1038/s43018-023-00632-w. Nat Cancer. 2023. PMID: 37580519 Free PMC article. No abstract available.
Interleukin 17 signaling supports clinical benefit of dual CTLA-4 and PD-1 checkpoint inhibition in melanoma.
Váraljai R, Zimmer L, Al-Matary Y, Kaptein P, Albrecht LJ, Shannan B, Brase JC, Gusenleitner D, Amaral T, Wyss N, Utikal J, Flatz L, Rambow F, Reinhardt HC, Dick J, Engel DR, Horn S, Ugurel S, Sondermann W, Livingstone E, Sucker A, Paschen A, Zhao F, Placke JM, Klose JM, Fendler WP, Thommen DS, Helfrich I, Schadendorf D, Roesch A. Váraljai R, et al. Among authors: helfrich i. Nat Cancer. 2023 Sep;4(9):1292-1308. doi: 10.1038/s43018-023-00610-2. Epub 2023 Jul 31. Nat Cancer. 2023. PMID: 37525015 Free PMC article.
Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs.
Spangenberg P, Hagemann N, Squire A, Förster N, Krauß SD, Qi Y, Mohamud Yusuf A, Wang J, Grüneboom A, Kowitz L, Korste S, Totzeck M, Cibir Z, Tuz AA, Singh V, Siemes D, Struensee L, Engel DR, Ludewig P, Martins Nascentes Melo L, Helfrich I, Chen J, Gunzer M, Hermann DM, Mosig A. Spangenberg P, et al. Among authors: helfrich i. Cell Rep Methods. 2023 Mar 17;3(3):100436. doi: 10.1016/j.crmeth.2023.100436. eCollection 2023 Mar 27. Cell Rep Methods. 2023. PMID: 37056368 Free PMC article.
Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma.
Martins Nascentes Melo L, Herrera-Rios D, Hinze D, Löffek S, Oezel I, Turiello R, Klein J, Leonardelli S, Westedt IV, Al-Matary Y, Egea-Rodriguez S, Brenzel A, Bau M, Sucker A, Hadaschik E, Wirsdörfer F, Hanenberg H, Uhlenbrock N, Rauh D, Poźniak J, Rambow F, Marine JC, Effern M, Glodde N, Schadendorf D, Jablonska J, Hölzel M, Helfrich I. Martins Nascentes Melo L, et al. Among authors: helfrich i. J Immunother Cancer. 2023 Apr 7;11(4):e004150. doi: 10.1136/jitc-2021-004150. J Immunother Cancer. 2023. PMID: 37028818 Free PMC article.
Active Remodeling of Capillary Endothelium via Cancer Cell-Derived MMP9 Promotes Metastatic Brain Colonization.
Karreman MA, Bauer AT, Solecki G, Berghoff AS, Mayer CD, Frey K, Hebach N, Feinauer MJ, Schieber NL, Tehranian C, Mercier L, Singhal M, Venkataramani V, Schubert MC, Hinze D, Hölzel M, Helfrich I, Schadendorf D, Schneider SW, Westphal D, Augustin HG, Goetz JG, Schwab Y, Wick W, Winkler F. Karreman MA, et al. Among authors: helfrich i. Cancer Res. 2023 Apr 14;83(8):1299-1314. doi: 10.1158/0008-5472.CAN-22-3964. Cancer Res. 2023. PMID: 36652557 Free PMC article.
53 results