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Catalytic-independent functions of the Integrator-PP2A complex (INTAC) confer sensitivity to BET inhibition.
Fan P, Shang XY, Song A, Chen S, Mao RY, Ma J, Chen J, Wang Z, Zheng H, Tao B, Hong L, Liu J, Xu W, Jiang W, Shen H, Zhang Q, Yang H, Meng XM, Lan F, Cheng J, Xu C, Zhang P, Jiang H, Chen FX. Fan P, et al. Among authors: cheng j. Nat Chem Biol. 2025 Jan 14. doi: 10.1038/s41589-024-01807-x. Online ahead of print. Nat Chem Biol. 2025. PMID: 39809894
R-loop-dependent promoter-proximal termination ensures genome stability.
Xu C, Li C, Chen J, Xiong Y, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H, Chen FX. Xu C, et al. Among authors: cheng j. Nature. 2023 Sep;621(7979):610-619. doi: 10.1038/s41586-023-06515-5. Epub 2023 Aug 9. Nature. 2023. PMID: 37557913 Free PMC article.
Author Correction: R-loop-dependent promoter-proximal termination ensures genome stability.
Xu C, Li C, Chen J, Xiong Y, Qiao Z, Fan P, Li C, Ma S, Liu J, Song A, Tao B, Xu T, Xu W, Chi Y, Xue J, Wang P, Ye D, Gu H, Zhang P, Wang Q, Xiao R, Cheng J, Zheng H, Yu X, Zhang Z, Wu J, Liang K, Liu YJ, Lu H, Chen FX. Xu C, et al. Among authors: cheng j. Nature. 2025 Jan 20. doi: 10.1038/s41586-025-08606-x. Online ahead of print. Nature. 2025. PMID: 39833484 No abstract available.
SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma.
Miao B, Ge L, He C, Wang X, Wu J, Li X, Chen K, Wan J, Xing S, Ren L, Shi Z, Liu S, Hu Y, Chen J, Yu Y, Feng L, Flores NM, Liang Z, Xu X, Wang R, Zhou J, Fan J, Xiang B, Li E, Mao Y, Cheng J, Zhao K, Mazur PK, Cai J, Lan F. Miao B, et al. Among authors: cheng j. Cell Res. 2024 Sep;34(9):648-660. doi: 10.1038/s41422-024-01013-3. Epub 2024 Aug 5. Cell Res. 2024. PMID: 39103523 Free PMC article.
Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
Osterman IA, Wieland M, Maviza TP, Lashkevich KA, Lukianov DA, Komarova ES, Zakalyukina YV, Buschauer R, Shiriaev DI, Leyn SA, Zlamal JE, Biryukov MV, Skvortsov DA, Tashlitsky VN, Polshakov VI, Cheng J, Polikanov YS, Bogdanov AA, Osterman AL, Dmitriev SE, Beckmann R, Dontsova OA, Wilson DN, Sergiev PV. Osterman IA, et al. Among authors: cheng j. Nat Chem Biol. 2020 Oct;16(10):1071-1077. doi: 10.1038/s41589-020-0578-x. Epub 2020 Jun 29. Nat Chem Biol. 2020. PMID: 32601485
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