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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis.
Figueroa-Valdés AI, Luz-Crawford P, Herrera-Luna Y, Georges-Calderón N, García C, Tobar HE, Araya MJ, Matas J, Donoso-Meneses D, de la Fuente C, Cuenca J, Parra E, Lillo F, Varela C, Cádiz MI, Vernal R, Ortloff A, Nardocci G, Castañeda V, Adasme-Vidal C, Kunze-Küllmer M, Hidalgo Y, Espinoza F, Khoury M, Alcayaga-Miranda F. Figueroa-Valdés AI, et al. Among authors: alcayaga miranda f. J Nanobiotechnology. 2025 Jan 13;23(1):13. doi: 10.1186/s12951-024-03088-x. J Nanobiotechnology. 2025. PMID: 39806427 Free PMC article.
Umbilical Cord-Derived Mesenchymal Stromal Cells (MSCs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial.
Matas J, Orrego M, Amenabar D, Infante C, Tapia-Limonchi R, Cadiz MI, Alcayaga-Miranda F, González PL, Muse E, Khoury M, Figueroa FE, Espinoza F. Matas J, et al. Stem Cells Transl Med. 2019 Mar;8(3):215-224. doi: 10.1002/sctm.18-0053. Epub 2018 Dec 28. Stem Cells Transl Med. 2019. PMID: 30592390 Free PMC article. Clinical Trial.
A Chemically Defined, Xeno- and Blood-Free Culture Medium Sustains Increased Production of Small Extracellular Vesicles From Mesenchymal Stem Cells.
Figueroa-Valdés AI, de la Fuente C, Hidalgo Y, Vega-Letter AM, Tapia-Limonchi R, Khoury M, Alcayaga-Miranda F. Figueroa-Valdés AI, et al. Among authors: alcayaga miranda f. Front Bioeng Biotechnol. 2021 May 26;9:619930. doi: 10.3389/fbioe.2021.619930. eCollection 2021. Front Bioeng Biotechnol. 2021. PMID: 34124014 Free PMC article.
Safety and efficacy of clinical-grade, cryopreserved menstrual blood mesenchymal stromal cells in experimental acute respiratory distress syndrome.
Alcayaga-Miranda F, Dutra Silva J, Parada N, Andrade da Silva LH, Ferreira Cruz F, Utreras Y, Hidalgo Y, Cádiz MI, Tapia Limonchi R, Espinoza F, Bruhn A, Khoury M, R M Rocco P, Cuenca J. Alcayaga-Miranda F, et al. Front Cell Dev Biol. 2023 Jan 30;11:1031331. doi: 10.3389/fcell.2023.1031331. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 36793446 Free PMC article.
24 results