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Page 1
Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Wei SC, Cantor AJ, Walleshauser J, Mepani R, Melton K, Bans A, Khekare P, Gupta S, Wang J, Soares C, Kiwan R, Lee J, McCawley S, Jani V, Leong WI, Shahi PK, Chan J, Boivin P, Otoupal P, Pattnaik BR, Gamm DM, Saha K, Gowen BG, Haak-Frendscho M, Janatpour MJ, Silverman AP. Wei SC, et al. Among authors: mepani r. bioRxiv [Preprint]. 2024 Dec 30:2024.12.30.630799. doi: 10.1101/2024.12.30.630799. bioRxiv. 2024. PMID: 39803585 Free PMC article. Preprint.
Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species.
Gowen BG, Khekare P, McCawley SR, Melton K, Soares C, Chan J, Jani V, Boivin P, Bans A, Leong WI, Cantor AJ, Walleshauser J, Otoupal PB, Mepani RJ, Silverman AP, Haak-Frendscho M, Wei SC. Gowen BG, et al. Among authors: mepani rj. CRISPR J. 2024 Dec;7(6):306-309. doi: 10.1089/crispr.2024.0053. Epub 2024 Sep 23. CRISPR J. 2024. PMID: 39308435 No abstract available.
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10.
Maeder ML, Stefanidakis M, Wilson CJ, Baral R, Barrera LA, Bounoutas GS, Bumcrot D, Chao H, Ciulla DM, DaSilva JA, Dass A, Dhanapal V, Fennell TJ, Friedland AE, Giannoukos G, Gloskowski SW, Glucksmann A, Gotta GM, Jayaram H, Haskett SJ, Hopkins B, Horng JE, Joshi S, Marco E, Mepani R, Reyon D, Ta T, Tabbaa DG, Samuelsson SJ, Shen S, Skor MN, Stetkiewicz P, Wang T, Yudkoff C, Myer VE, Albright CF, Jiang H. Maeder ML, et al. Among authors: mepani r. Nat Med. 2019 Feb;25(2):229-233. doi: 10.1038/s41591-018-0327-9. Epub 2019 Jan 21. Nat Med. 2019. PMID: 30664785
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis.
Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. Ye L, et al. Among authors: mepani rj. Cell. 2012 Sep 28;151(1):96-110. doi: 10.1016/j.cell.2012.08.034. Cell. 2012. PMID: 23021218 Free PMC article.
Development of insulin resistance in mice lacking PGC-1α in adipose tissues.
Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Kleiner S, et al. Among authors: mepani rj. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9635-40. doi: 10.1073/pnas.1207287109. Epub 2012 May 29. Proc Natl Acad Sci U S A. 2012. PMID: 22645355 Free PMC article.
Transcriptional control of preadipocyte determination by Zfp423.
Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Gupta RK, et al. Among authors: mepani rj. Nature. 2010 Mar 25;464(7288):619-23. doi: 10.1038/nature08816. Epub 2010 Mar 3. Nature. 2010. PMID: 20200519 Free PMC article.
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