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Page 1
Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.
Yoffe L, Bhinder B, Kang SW, Zhang H, Singh A, Ravichandran H, Markowitz G, Martin M, Kim J, Zhang C, Elemento O, Tansey W, Bates S, McGraw TE, Borczuk A, Lee HS, Altorki NK, Mittal V. Yoffe L, et al. Among authors: altorki nk. bioRxiv [Preprint]. 2025 Jan 1:2024.12.31.630523. doi: 10.1101/2024.12.31.630523. bioRxiv. 2025. PMID: 39803458 Free PMC article. Preprint.
Transferrin receptor-based circulating tumor cell enrichment provides a snapshot of the molecular landscape of solid tumors and correlates with clinical outcomes.
Galletti G, Halima A, Gjyrezi A, Zhang J, Zimmerman B, Worroll D, Kallergi G, Barreja R, Ocean A, Saxena A, McGraw TE, Nanus DM, Elemento O, Altorki NK, Tagawa ST, Giannakakou P. Galletti G, et al. Among authors: altorki nk. medRxiv [Preprint]. 2024 Jun 17:2024.06.16.24309003. doi: 10.1101/2024.06.16.24309003. medRxiv. 2024. PMID: 38947080 Free PMC article. Preprint.
Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve immunotherapy.
Markowitz GJ, Ban Y, Tavarez DA, Yoffe L, Podaza E, He Y, Martin MT, Crowley MJP, Sandoval TA, Gao D, Martin ML, Elemento O, Cubillos-Ruiz JR, McGraw TE, Altorki NK, Mittal V. Markowitz GJ, et al. Among authors: altorki nk. Nat Immunol. 2024 Oct;25(10):1884-1899. doi: 10.1038/s41590-024-01963-1. Epub 2024 Sep 26. Nat Immunol. 2024. PMID: 39327500
Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment.
Widman AJ, Shah M, Frydendahl A, Halmos D, Khamnei CC, Øgaard N, Rajagopalan S, Arora A, Deshpande A, Hooper WF, Quentin J, Bass J, Zhang M, Langanay T, Andersen L, Steinsnyder Z, Liao W, Rasmussen MH, Henriksen TV, Jensen SØ, Nors J, Therkildsen C, Sotelo J, Brand R, Schiffman JS, Shah RH, Cheng AP, Maher C, Spain L, Krause K, Frederick DT, den Brok W, Lohrisch C, Shenkier T, Simmons C, Villa D, Mungall AJ, Moore R, Zaikova E, Cerda V, Kong E, Lai D, Malbari MS, Marton M, Manaa D, Winterkorn L, Gelmon K, Callahan MK, Boland G, Potenski C, Wolchok JD, Saxena A, Turajlic S, Imielinski M, Berger MF, Aparicio S, Altorki NK, Postow MA, Robine N, Andersen CL, Landau DA. Widman AJ, et al. Among authors: altorki nk. Nat Med. 2024 Jun;30(6):1655-1666. doi: 10.1038/s41591-024-03040-4. Epub 2024 Jun 14. Nat Med. 2024. PMID: 38877116 Free PMC article.
Is Moving Beyond Nodal Staging a Bridge Too Far?
Chow OS, Altorki NK. Chow OS, et al. Among authors: altorki nk. Ann Thorac Surg. 2025 Jan;119(1):199-200. doi: 10.1016/j.athoracsur.2024.04.008. Epub 2024 Apr 24. Ann Thorac Surg. 2025. PMID: 38663660 No abstract available.
Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
Madorsky Rowdo FP, Xiao G, Khramtsova GF, Nguyen J, Martini R, Stonaker B, Boateng R, Oppong JK, Adjei EK, Awuah B, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, Osei-Bonsu EB, Gyan KK, Altorki NK, Cheng E, Ginter PS, Hoda S, Newman L, Elemento O, Olopade OI, Davis MB, Martin ML, Bargonetti J. Madorsky Rowdo FP, et al. Among authors: altorki nk. Cancer Lett. 2024 Mar 1;584:216608. doi: 10.1016/j.canlet.2024.216608. Epub 2024 Jan 9. Cancer Lett. 2024. PMID: 38199587 Free article.
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
Altorki NK, Walsh ZH, Melms JC, Port JL, Lee BE, Nasar A, Spinelli C, Caprio L, Rogava M, Ho P, Christos PJ, Saxena A, Elemento O, Bhinder B, Ager C, Amin AD, Sanfilippo NJ, Mittal V, Borczuk AC, Formenti SC, Izar B, McGraw TE. Altorki NK, et al. Nat Commun. 2024 Jan 3;15(1):225. doi: 10.1038/s41467-023-44575-3. Nat Commun. 2024. PMID: 38172131 Free PMC article. No abstract available.
Radiologic Features of Nodules Attached to the Mediastinal or Diaphragmatic Pleura at Low-Dose CT for Lung Cancer Screening.
Zhu Y, Yip R, Zhang J, Cai Q, Sun Q, Li P, Paksashvili N, Triphuridet N, Henschke CI, Yankelevitz DF; Investigators of the International Early Lung Cancer Action Program and Initiative for Early Lung Cancer Research on Treatment–Mount Sinai Health System; Investigators of the International Early Lung Cancer Action Program; Investigators of the Initiative for Early Lung Cancer Research on Treatment–Mount Sinai Health System. Zhu Y, et al. Radiology. 2024 Jan;310(1):e231219. doi: 10.1148/radiol.231219. Radiology. 2024. PMID: 38165250 Free PMC article.
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