El-Lakkany NM - Search Results

1

Gossypol enhances ponatinib's cytotoxicity against human hepatocellular carcinoma cells by involving cell cycle arrest, p-AKT/LC3II/p62, and Bcl2/caspase-3 pathways.

Elkattan HH, Elsisi AE, El-Lakkany NM. Elkattan HH, et al. Among authors: el lakkany nm. Toxicol Rep. 2024 Dec 11;14:101856. doi: 10.1016/j.toxrep.2024.101856. eCollection 2025 Jun. Toxicol Rep. 2024. PMID: 39802605 Free PMC article.

2

Bacillus clausii spores maintain gut homeostasis in murine ulcerative colitis via modulating microbiota, apoptosis, and the TXNIP/NLRP3 inflammasome cascade.

Salem MB, El-Lakkany NM, Hammam OA, Seif El-Din SH. Salem MB, et al. Among authors: el lakkany nm. Toxicol Rep. 2024 Dec 16;14:101858. doi: 10.1016/j.toxrep.2024.101858. eCollection 2025 Jun. Toxicol Rep. 2024. PMID: 39802600 Free PMC article.

3

Diosmin alleviates ulcerative colitis in mice by increasing Akkermansia muciniphila abundance, improving intestinal barrier function, and modulating the NF-κB and Nrf2 pathways.

Salem MB, El-Lakkany NM, Seif El-Din SH, Hammam OA, Samir S. Salem MB, et al. Among authors: el lakkany nm. Heliyon. 2024 Mar 7;10(6):e27527. doi: 10.1016/j.heliyon.2024.e27527. eCollection 2024 Mar 30. Heliyon. 2024. PMID: 38500992 Free PMC article.

4

Molecular docking, characterization, ADME/toxicity prediction, and anti-ulcer activity of new quercetin derivatives on indomethacin-induced gastric ulcer in mice.

Salem MB, Saleh AM, Seif El-Din SH, Samir S, Hammam OA, El-Lakkany NM. Salem MB, et al. Among authors: el lakkany nm. Toxicol Appl Pharmacol. 2024 Mar;484:116880. doi: 10.1016/j.taap.2024.116880. Epub 2024 Mar 4. Toxicol Appl Pharmacol. 2024. PMID: 38447874

5

Vildagliptin alleviates liver fibrosis in NASH diabetic rats via modulation of insulin resistance, oxidative stress, and inflammatory cascades.

Hendawy AS, El-Lakkany NM, Mantawy EM, Hammam OA, Botros SS, El-Demerdash E. Hendawy AS, et al. Among authors: el lakkany nm. Life Sci. 2022 Sep 1;304:120695. doi: 10.1016/j.lfs.2022.120695. Epub 2022 Jun 4. Life Sci. 2022. PMID: 35671811

6

Itraconazole, a cytochrome P450 inhibitor, enhanced the efficacy of praziquantel against Schistosoma mansoni infection and alleviated liver injury in mice.

Sabra AA, Salem MB, William S, Hammam OA, El-Lakkany NM. Sabra AA, et al. Among authors: el lakkany nm. Exp Parasitol. 2022 Aug;239:108293. doi: 10.1016/j.exppara.2022.108293. Epub 2022 Jun 3. Exp Parasitol. 2022. PMID: 35667394

7

The ponatinib/gossypol novel combination provides enhanced anticancer activity against murine solid Ehrlich carcinoma via triggering apoptosis and inhibiting proliferation/angiogenesis.

El-Lakkany NM, Elkattan HH, Elsisi AE. El-Lakkany NM, et al. Toxicol Appl Pharmacol. 2021 Dec 1;432:115767. doi: 10.1016/j.taap.2021.115767. Epub 2021 Oct 23. Toxicol Appl Pharmacol. 2021. PMID: 34699866

8

Early intervention with probiotics and metformin alleviates liver injury in NAFLD rats via targeting gut microbiota dysbiosis and p-AKT/mTOR/LC-3II pathways.

Seif El-Din SH, Salem MB, El-Lakkany NM, Hammam OA, Nasr SM, Okasha H, Ahmed LA, Saleh S, Botros SS. Seif El-Din SH, et al. Among authors: el lakkany nm. Hum Exp Toxicol. 2021 Sep;40(9):1496-1509. doi: 10.1177/0960327121999445. Epub 2021 Mar 8. Hum Exp Toxicol. 2021. PMID: 33678036

9

Gut microbiota modulation as a promising therapy with metformin in rats with non-alcoholic steatohepatitis: Role of LPS/TLR4 and autophagy pathways.

Ahmed LA, Salem MB, Seif El-Din SH, El-Lakkany NM, Ahmed HO, Nasr SM, Hammam OA, Botros SS, Saleh S. Ahmed LA, et al. Among authors: el lakkany nm. Eur J Pharmacol. 2020 Nov 15;887:173461. doi: 10.1016/j.ejphar.2020.173461. Epub 2020 Aug 3. Eur J Pharmacol. 2020. PMID: 32758573

10

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools.

Sebastian-Perez V, García-Rubia A, Seif El-Din SH, Sabra AA, El-Lakkany NM, William S, Blundell TL, Maes L, Martinez A, Campillo NE, Botros SS, Gil C. Sebastian-Perez V, et al. Among authors: el lakkany nm. J Enzyme Inhib Med Chem. 2020 Dec;35(1):511-523. doi: 10.1080/14756366.2020.1712595. J Enzyme Inhib Med Chem. 2020. PMID: 31939312 Free PMC article.

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