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Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial.
Brennan PN, MacMillan M, Manship T, Moroni F, Glover A, Troland D, MacPherson I, Graham C, Aird R, Semple SIK, Morris DM, Fraser AR, Pass C, McGowan NWA, Turner ML, Manson L, Lachlan NJ, Dillon JF, Kilpatrick AM, Campbell JDM, Fallowfield JA, Forbes SJ. Brennan PN, et al. Among authors: forbes sj. Nat Med. 2025 Jan 10. doi: 10.1038/s41591-024-03406-8. Online ahead of print. Nat Med. 2025. PMID: 39794616
Host hepatocyte senescence determines the success of hepatocyte transplantation in a mouse model of liver injury.
Gadd VL, Ferreira-Gonzalez S, Man TY, Kilpatrick AM, Aird RE, Smith IP, Rodrigo-Torres D, Kurian D, Hallett JM, Ashmore-Harris C, Esser H, Ferreira MF, Macmillan MT, Lu WY, Forbes SJ. Gadd VL, et al. Among authors: forbes sj. J Hepatol. 2025 Jan 2:S0168-8278(24)02830-7. doi: 10.1016/j.jhep.2024.12.039. Online ahead of print. J Hepatol. 2025. PMID: 39755157 Free article.
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK.
Humphries C, Addison M, Aithal G, Boyd J, Briody L, Campbell JDM, Candela ME, Clarke E, Coulson J, Downing-James N, Fontana RJ, Geddes A, Grahamslaw J, Grant A, Heye A, Hutchinson JA, Jones A, Mitchell F, Moore J, Riddell A, Rodriguez A, Thomas A, Tucker G, Walker K, Weir CJ, Woods R, Zahra S, Forbes SJ, Dear JW. Humphries C, et al. Among authors: forbes sj. BMJ Open. 2024 Dec 9;14(12):e089417. doi: 10.1136/bmjopen-2024-089417. BMJ Open. 2024. PMID: 39653576 Free PMC article.
NIBR-LTSi is a selective LATS kinase inhibitor activating YAP signaling and expanding tissue stem cells in vitro and in vivo.
Namoto K, Baader C, Orsini V, Landshammer A, Breuer E, Dinh KT, Ungricht R, Pikiolek M, Laurent S, Lu B, Aebi A, Schönberger K, Vangrevelinghe E, Evrova O, Sun T, Annunziato S, Lachal J, Redmond E, Wang L, Wetzel K, Capodieci P, Turner J, Schutzius G, Unterreiner V, Trunzer M, Buschmann N, Behnke D, Machauer R, Scheufler C, Parker CN, Ferro M, Grevot A, Beyerbach A, Lu WY, Forbes SJ, Wagner J, Bouwmeester T, Liu J, Sohal B, Sahambi S, Greenbaum LE, Lohmann F, Hoppe P, Cong F, Sailer AW, Ruffner H, Glatthar R, Humar B, Clavien PA, Dill MT, George E, Maibaum J, Liberali P, Tchorz JS. Namoto K, et al. Among authors: forbes sj. Cell Stem Cell. 2024 Apr 4;31(4):554-569.e17. doi: 10.1016/j.stem.2024.03.003. Cell Stem Cell. 2024. PMID: 38579685
Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo.
Gonzalez Galofre ZN, Kilpatrick AM, Marques M, Sá da Bandeira D, Ventura T, Gomez Salazar M, Bouilleau L, Marc Y, Barbosa AB, Rossi F, Beltran M, van de Werken HJG, van IJcken WFJ, Henderson NC, Forbes SJ, Crisan M. Gonzalez Galofre ZN, et al. Among authors: forbes sj. Nat Commun. 2024 Feb 23;15(1):1653. doi: 10.1038/s41467-024-44913-z. Nat Commun. 2024. PMID: 38395882 Free PMC article.
190 results