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Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker BJ, Gardner M, Guinn KM, Howard NC, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: zhu j. Nat Microbiol. 2025 Jan 10. doi: 10.1038/s41564-024-01913-5. Online ahead of print. Nat Microbiol. 2025. PMID: 39794471
Spatiotemporal perspectives on tuberculosis chemotherapy.
Zhu J, Liu YJ, Fortune SM. Zhu J, et al. Curr Opin Microbiol. 2023 Apr;72:102266. doi: 10.1016/j.mib.2023.102266. Epub 2023 Feb 4. Curr Opin Microbiol. 2023. PMID: 36745965 Free PMC article. Review.
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker B, Gardner M, Guinn KM, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: zhu j. bioRxiv [Preprint]. 2023 Nov 19:2023.11.19.567569. doi: 10.1101/2023.11.19.567569. bioRxiv. 2023. PMID: 38014062 Free PMC article. Preprint.
Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.
Luo Y, Huang CC, Howard NC, Wang X, Liu Q, Li X, Zhu J, Amariuta T, Asgari S, Ishigaki K, Calderon R, Raman S, Ramnarine AK, Mayfield JA, Moody DB, Lecca L, Fortune SM, Murray MB, Raychaudhuri S. Luo Y, et al. Among authors: zhu j. Nat Commun. 2024 Nov 29;15(1):10393. doi: 10.1038/s41467-024-54741-w. Nat Commun. 2024. PMID: 39613754 Free PMC article.
Tuberculosis treatment failure associated with evolution of antibiotic resilience.
Liu Q, Zhu J, Dulberger CL, Stanley S, Wilson S, Chung ES, Wang X, Culviner P, Liu YJ, Hicks ND, Babunovic GH, Giffen SR, Aldridge BB, Garner EC, Rubin EJ, Chao MC, Fortune SM. Liu Q, et al. Among authors: zhu j. Science. 2022 Dec 9;378(6624):1111-1118. doi: 10.1126/science.abq2787. Epub 2022 Dec 8. Science. 2022. PMID: 36480634 Free PMC article.
Mycobacterial nucleoid-associated protein Lsr2 is required for productive mycobacteriophage infection.
Dulberger CL, Guerrero-Bustamante CA, Owen SV, Wilson S, Wuo MG, Garlena RA, Serpa LA, Russell DA, Zhu J, Braunecker BJ, Squyres GR, Baym M, Kiessling LL, Garner EC, Rubin EJ, Hatfull GF. Dulberger CL, et al. Among authors: zhu j. Nat Microbiol. 2023 Apr;8(4):695-710. doi: 10.1038/s41564-023-01333-x. Epub 2023 Feb 23. Nat Microbiol. 2023. PMID: 36823286 Free PMC article.
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