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Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker BJ, Gardner M, Guinn KM, Howard NC, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: sixsmith j. Nat Microbiol. 2025 Jan 10. doi: 10.1038/s41564-024-01913-5. Online ahead of print. Nat Microbiol. 2025. PMID: 39794471
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model.
Wang X, Su H, Wallach JB, Wagner JC, Braunecker B, Gardner M, Guinn KM, Klevorn T, Lin K, Liu YJ, Liu Y, Mugahid D, Rodgers M, Sixsmith J, Wakabayashi S, Zhu J, Zimmerman M, Dartois V, Flynn JL, Lin PL, Ehrt S, Fortune SM, Rubin EJ, Schnappinger D. Wang X, et al. Among authors: sixsmith j. bioRxiv [Preprint]. 2023 Nov 19:2023.11.19.567569. doi: 10.1101/2023.11.19.567569. bioRxiv. 2023. PMID: 38014062 Free PMC article. Preprint.
Fc-engineered antibodies promote neutrophil-dependent control of Mycobacterium tuberculosis.
Irvine EB, Nikolov A, Khan MZ, Peters JM, Lu R, Sixsmith J, Wallace A, van Woudenbergh E, Shin S, Karpinski W, Hsiao JC, Casadevall A, Bryson BD, Cavacini L, Grace PS, Alter G, Fortune SM. Irvine EB, et al. Among authors: sixsmith j. Nat Microbiol. 2024 Sep;9(9):2369-2382. doi: 10.1038/s41564-024-01777-9. Epub 2024 Aug 22. Nat Microbiol. 2024. PMID: 39174703 Free PMC article.
Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.
Grace PS, Peters JM, Sixsmith J, Lu R, Luedeman C, Fenderson BA, Vickers A, Slein MD, Irvine EB, McKitrick T, Wei MH, Cummings RD, Wallace A, Cavacini LA, Choudhary A, Proulx MK, Sundling C, Källenius G, Reljic R, Ernst JD, Casadevall A, Locht C, Pinter A, Sasseti CM, Bryson BD, Fortune SM, Alter G. Grace PS, et al. Among authors: sixsmith j. bioRxiv [Preprint]. 2024 Oct 11:2024.10.07.617070. doi: 10.1101/2024.10.07.617070. bioRxiv. 2024. PMID: 39416184 Free PMC article. Preprint.
Stable Expression of Lentiviral Antigens by Quality-Controlled Recombinant Mycobacterium bovis BCG Vectors.
Hart BE, Asrican R, Lim SY, Sixsmith JD, Lukose R, Souther SJ, Rayasam SD, Saelens JW, Chen CJ, Seay SA, Berney-Meyer L, Magtanong L, Vermeul K, Pajanirassa P, Jimenez AE, Ng TW, Tobin DM, Porcelli SA, Larsen MH, Schmitz JE, Haynes BF, Jacobs WR Jr, Lee S, Frothingham R. Hart BE, et al. Among authors: sixsmith jd. Clin Vaccine Immunol. 2015 Jul;22(7):726-41. doi: 10.1128/CVI.00075-15. Epub 2015 Apr 29. Clin Vaccine Immunol. 2015. PMID: 25924766 Free PMC article.
92 results