Wang W - Search Results

1

Probing into the plasma stability and microsomal stability of thiol-based prodrug derivatives: Using IYS-15, an HDAC inhibitor as the model thiol.

Zhu L, Wang W, Li Q, Wang H, Lei X. Zhu L, et al. Among authors: wang h, wang w. Bioorg Med Chem. 2025 Jan 5;119:118064. doi: 10.1016/j.bmc.2025.118064. Online ahead of print. Bioorg Med Chem. 2025. PMID: 39793402

2

Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities.

Zhang X, Wang W, Dong G, Song Y, Zhai X, Sheng C. Zhang X, et al. Among authors: wang w. Bioorg Med Chem Lett. 2024 Sep 1;109:129838. doi: 10.1016/j.bmcl.2024.129838. Epub 2024 Jun 3. Bioorg Med Chem Lett. 2024. PMID: 38838918

3

Discovery of potent NAMPT-Targeting PROTACs using FK866 as the warhead.

Zhang P, Wang W, Guo M, Zhou L, Dong G, Xu D, Sheng C. Zhang P, et al. Among authors: wang w. Bioorg Med Chem Lett. 2023 Aug 15;92:129393. doi: 10.1016/j.bmcl.2023.129393. Epub 2023 Jun 25. Bioorg Med Chem Lett. 2023. PMID: 37369332

4

Discovery of 2H-Indazole-3-carboxamide Derivatives as Novel Potent Prostanoid EP4 Receptor Antagonists for Colorectal Cancer Immunotherapy.

Cheng Z, Wang Y, Zhang Y, Zhang C, Wang M, Wang W, He J, Wang Y, Zhang H, Zhang Q, Ding C, Wu D, Yang L, Liu M, Lu W. Cheng Z, et al. Among authors: wang w, wang y, wang m. J Med Chem. 2023 May 11;66(9):6218-6238. doi: 10.1021/acs.jmedchem.2c02058. Epub 2023 Mar 7. J Med Chem. 2023. PMID: 36880691

5

Subtle Structural Modifications Spanning from EP4 Antagonism to EP2/EP4 Dual Antagonism: A Novel Class of Thienocyclic-Based Derivatives.

Cheng Z, Zhang Y, Du L, Wang W, Chai X, He M, Zhang H, Wu D, Lu J, Zhang S, Feng B, Yang L, Liu M, Lu W. Cheng Z, et al. Among authors: wang w. J Med Chem. 2025 Jan 23;68(2):1587-1607. doi: 10.1021/acs.jmedchem.4c02241. Epub 2025 Jan 6. J Med Chem. 2025. PMID: 39757828

6

Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy.

Wang W, He J, Yang J, Zhang C, Cheng Z, Zhang Y, Zhang Q, Wang P, Tang S, Wang X, Liu M, Lu W, Zhang HK. Wang W, et al. Among authors: wang x, wang p. J Med Chem. 2022 Jun 9;65(11):7896-7917. doi: 10.1021/acs.jmedchem.2c00448. Epub 2022 May 31. J Med Chem. 2022. PMID: 35640059

7

Synthesis and cytotoxic activities of beta-carboline amino acid ester conjugates.

Zhao M, Bi L, Wang W, Wang C, Baudy-Floc'h M, Ju J, Peng S. Zhao M, et al. Among authors: wang w, wang c. Bioorg Med Chem. 2006 Oct 15;14(20):6998-7010. doi: 10.1016/j.bmc.2006.06.021. Epub 2006 Jun 27. Bioorg Med Chem. 2006. PMID: 16806943

8

Synthesis, anti-fungal and 1,3-β-D-glucan synthase inhibitory activities of caffeic and quinic acid derivatives.

Ma CM, Abe T, Komiyama T, Wang W, Hattori M, Daneshtalab M. Ma CM, et al. Among authors: wang w. Bioorg Med Chem. 2010 Oct 1;18(19):7009-14. doi: 10.1016/j.bmc.2010.08.022. Epub 2010 Aug 13. Bioorg Med Chem. 2010. PMID: 20813534

9

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies.

Devasthale P, Wang W, Mignone J, Renduchintala K, Radhakrishnan S, Dhanapal J, Selvaraj J, Kuppusamy R, Pelleymounter MA, Longhi D, Huang N, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas M, Glick S, Godonis H, Harvey S, Cullen MJ, Zhang H, Caporuscio C, Stetsko P, Grubb M, Huang C, Zhang L, Freeden C, Murphy BJ, Robl JA, Washburn WN. Devasthale P, et al. Among authors: wang w. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4412-8. doi: 10.1016/j.bmcl.2015.09.018. Epub 2015 Sep 8. Bioorg Med Chem Lett. 2015. PMID: 26386604

10

Lysine-Tethered Stable Bicyclic Cationic Antimicrobial Peptide Combats Bacterial Infection in Vivo.

He T, Xu L, Hu Y, Tang X, Qu R, Zhao X, Bai H, Li L, Chen W, Luo G, Fu G, Wang W, Xia X, Zhang J. He T, et al. Among authors: wang w. J Med Chem. 2022 Aug 11;65(15):10523-10533. doi: 10.1021/acs.jmedchem.2c00661. Epub 2022 Aug 3. J Med Chem. 2022. PMID: 35920072

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