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Mechanism-guided engineering of a minimal biological particle for genome editing.
Ngo W, Peukes J, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA. Ngo W, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2413519121. doi: 10.1073/pnas.2413519121. Epub 2024 Dec 30. Proc Natl Acad Sci U S A. 2025. PMID: 39793042 Free PMC article.
Mapping proteolytic neo-N termini at the surface of living cells.
Weeks AM, Byrnes JR, Lui I, Wells JA. Weeks AM, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2018809118. doi: 10.1073/pnas.2018809118. Proc Natl Acad Sci U S A. 2021. PMID: 33536314 Free PMC article.
A common allosteric site and mechanism in caspases.
Scheer JM, Romanowski MJ, Wells JA. Scheer JM, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7595-600. doi: 10.1073/pnas.0602571103. Epub 2006 May 8. Proc Natl Acad Sci U S A. 2006. PMID: 16682620 Free PMC article.
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
Glasgow A, Glasgow J, Limonta D, Solomon P, Lui I, Zhang Y, Nix MA, Rettko NJ, Zha S, Yamin R, Kao K, Rosenberg OS, Ravetch JV, Wiita AP, Leung KK, Lim SA, Zhou XX, Hobman TC, Kortemme T, Wells JA. Glasgow A, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28046-28055. doi: 10.1073/pnas.2016093117. Epub 2020 Oct 22. Proc Natl Acad Sci U S A. 2020. PMID: 33093202 Free PMC article.
Switchable assembly and function of antibody complexes in vivo using a small molecule.
Martinko AJ, Simonds EF, Prasad S, Ponce A, Bracken CJ, Wei J, Wang YH, Chow TL, Huang Z, Evans MJ, Wells JA, Hill ZB. Martinko AJ, et al. Among authors: wells ja. Proc Natl Acad Sci U S A. 2022 Mar 1;119(9):e2117402119. doi: 10.1073/pnas.2117402119. Proc Natl Acad Sci U S A. 2022. PMID: 35210365 Free PMC article.
526 results