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Mechanism-guided engineering of a minimal biological particle for genome editing.
Ngo W, Peukes J, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA. Ngo W, et al. Among authors: doudna ja. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2413519121. doi: 10.1073/pnas.2413519121. Epub 2024 Dec 30. Proc Natl Acad Sci U S A. 2025. PMID: 39793042 Free PMC article.
Mechanism-guided engineering of a minimal biological particle for genome editing.
Ngo W, Peukes JT, Baldwin A, Xue ZW, Hwang S, Stickels RR, Lin Z, Satpathy AT, Wells JA, Schekman R, Nogales E, Doudna JA. Ngo W, et al. Among authors: doudna ja. bioRxiv [Preprint]. 2024 Jul 24:2024.07.23.604809. doi: 10.1101/2024.07.23.604809. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2413519121. doi: 10.1073/pnas.2413519121 PMID: 39091760 Free PMC article. Updated. Preprint.
DNA Targeting by a Minimal CRISPR RNA-Guided Cascade.
Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA. Hochstrasser ML, et al. Among authors: doudna ja. Mol Cell. 2016 Sep 1;63(5):840-51. doi: 10.1016/j.molcel.2016.07.027. Mol Cell. 2016. PMID: 27588603 Free PMC article.
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Tsuchida CA, Zhang S, Doost MS, Zhao Y, Wang J, O'Brien E, Fang H, Li CP, Li D, Hai ZY, Chuck J, Brötzmann J, Vartoumian A, Burstein D, Chen XW, Nogales E, Doudna JA, Liu JG. Tsuchida CA, et al. Among authors: doudna ja. Mol Cell. 2022 Mar 17;82(6):1199-1209.e6. doi: 10.1016/j.molcel.2022.02.002. Epub 2022 Feb 25. Mol Cell. 2022. PMID: 35219382 Free PMC article.
CRISPR-Cas9 bends and twists DNA to read its sequence.
Cofsky JC, Soczek KM, Knott GJ, Nogales E, Doudna JA. Cofsky JC, et al. Among authors: doudna ja. Nat Struct Mol Biol. 2022 Apr;29(4):395-402. doi: 10.1038/s41594-022-00756-0. Epub 2022 Apr 14. Nat Struct Mol Biol. 2022. PMID: 35422516 Free PMC article.
In vivo human T cell engineering with enveloped delivery vehicles.
Hamilton JR, Chen E, Perez BS, Sandoval Espinoza CR, Kang MH, Trinidad M, Ngo W, Doudna JA. Hamilton JR, et al. Among authors: doudna ja. Nat Biotechnol. 2024 Nov;42(11):1684-1692. doi: 10.1038/s41587-023-02085-z. Epub 2024 Jan 11. Nat Biotechnol. 2024. PMID: 38212493 Free PMC article.
Disabling Cas9 by an anti-CRISPR DNA mimic.
Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Shin J, et al. Among authors: doudna ja. Sci Adv. 2017 Jul 12;3(7):e1701620. doi: 10.1126/sciadv.1701620. eCollection 2017 Jul. Sci Adv. 2017. PMID: 28706995 Free PMC article.
Structures of the CRISPR genome integration complex.
Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA. Wright AV, et al. Among authors: doudna ja. Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20. Science. 2017. PMID: 28729350 Free PMC article.
Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
Jiang F, Liu JJ, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J, Doudna JA. Jiang F, et al. Among authors: doudna ja. Mol Cell. 2019 Feb 7;73(3):601-610.e5. doi: 10.1016/j.molcel.2018.11.016. Epub 2018 Dec 27. Mol Cell. 2019. PMID: 30595438 Free PMC article.
393 results