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Page 1
Biomarkers.
Okamura N, Hiraoka K, Kobayashi R, Tomita N, Ishiki A, Mesfin B, Wu Y, Harada R, Kikuchi A, Takeda K, Kikuchi A, Furukawa K, Watabe H, Mugikura S, Kawakatsu S, Ishii K, Nihashi T, Kato T, Furumoto S, Tashiro M. Okamura N, et al. Alzheimers Dement. 2024 Dec;20 Suppl 2(Suppl 2):e086707. doi: 10.1002/alz.086707. Alzheimers Dement. 2024. PMID: 39786292 Free PMC article.
BACKGROUND: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous neurological conditions. PET tracers targeting monoamine oxidase B (MAO-B) are used to visualize reactive astrogliosis in the l …
BACKGROUND: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous n …
Biomarkers.
Mao A, Flassbeck S, Marchetto E, Rusinek H, Assländer J. Mao A, et al. Alzheimers Dement. 2024 Dec;20 Suppl 2(Suppl 2):e087669. doi: 10.1002/alz.087669. Alzheimers Dement. 2024. PMID: 39786016 Free PMC article.
Biomarkers.
Seredenina T. Seredenina T. Alzheimers Dement. 2024 Dec;20 Suppl 2(Suppl 2):e083411. doi: 10.1002/alz.083411. Alzheimers Dement. 2024. PMID: 39785694 Free PMC article.
ACI-19626 displays selectivity for TDP-43 over Abeta, Tau and alpha-synuclein aggregates, and no binding to common off-target proteins, including monoamine oxidase A and B. In monkeys, [(18)F]ACI-19626 has a rapid brain uptake and fast and complete washout, a profil …
ACI-19626 displays selectivity for TDP-43 over Abeta, Tau and alpha-synuclein aggregates, and no binding to common off-target proteins, incl …
Alzheimer's Imaging Consortium.
Mao A, Flassbeck S, Marchetto E, Rusinek H, Assländer J. Mao A, et al. Alzheimers Dement. 2024 Dec;20 Suppl 9(Suppl 9):e093741. doi: 10.1002/alz.093741. Alzheimers Dement. 2024. PMID: 39783070 Free PMC article.
Alzheimer's Imaging Consortium.
Okamura N, Hiraoka K, Kobayashi R, Tomita N, Ishiki A, Mesfin B, Wu Y, Harada R, Kikuchi A, Takeda K, Kikuchi A, Furukawa K, Watabe H, Mugikura S, Kawakatsu S, Ishii K, Nihashi T, Kato T, Furumoto S, Tashiro M. Okamura N, et al. Alzheimers Dement. 2024 Dec;20 Suppl 9(Suppl 9):e093700. doi: 10.1002/alz.093700. Alzheimers Dement. 2024. PMID: 39783056 Free PMC article.
BACKGROUND: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous neurological conditions. PET tracers targeting monoamine oxidase B (MAO-B) are used to visualize reactive astrogliosis in the l …
BACKGROUND: Reactive astrogliosis refers to functional and morphological changes in astrocytes that occur with neuronal damage in numerous n …
Drug Development.
Aro OP, Adefegha AS, Ogunsuyi OB, Oboh G. Aro OP, et al. Alzheimers Dement. 2024 Dec;20 Suppl 6(Suppl 6):e088477. doi: 10.1002/alz.088477. Alzheimers Dement. 2024. PMID: 39782614 Free PMC article.
In addition, when compared to their elevated levels in paraquat-induced flies, monoamine oxidase and acetylcholinesterase activities in the treated groups were found to be significantly (P<0.05) reduced. ...
In addition, when compared to their elevated levels in paraquat-induced flies, monoamine oxidase and acetylcholinesterase acti …
Drug Development.
Ajeigbe OF, Ademosun AO, Oboh G, Lawrence BO. Ajeigbe OF, et al. Alzheimers Dement. 2024 Dec;20 Suppl 6(Suppl 6):e085050. doi: 10.1002/alz.085050. Alzheimers Dement. 2024. PMID: 39782503 Free PMC article.
RESULT: Coadministration of CNB, TMD, and CDE was seen to led to the significant decrease in cognitive function, acetyl-cholinesterase (AChE), butyl-cholinesterase (BChE), monoamine oxidase (MAO) enzyme activities, and antioxidant enzyme activities in rats' brains w …
RESULT: Coadministration of CNB, TMD, and CDE was seen to led to the significant decrease in cognitive function, acetyl-cholinesterase (AChE …
The gut-brain axis underlying hepatic encephalopathy in liver cirrhosis.
He X, Hu M, Xu Y, Xia F, Tan Y, Wang Y, Xiang H, Wu H, Ji T, Xu Q, Wang L, Huang Z, Sun M, Wan Y, Cui P, Liang S, Pan Y, Xiao S, He Y, Song R, Yan J, Quan X, Wei Y, Hong C, Liao W, Li F, El-Omar E, Chen J, Qi X, Gao J, Zhou H. He X, et al. Nat Med. 2025 Jan 8. doi: 10.1038/s41591-024-03405-9. Online ahead of print. Nat Med. 2025. PMID: 39779925
This accumulation of PEA was primarily driven by decreased monoamine oxidase-B activity in both the liver and serum due to cirrhosis. Targeting PDC or PEA reversed the neurological symptoms induced by R. gnavus. ...
This accumulation of PEA was primarily driven by decreased monoamine oxidase-B activity in both the liver and serum due to cir …
Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets.
Lü J, Jiang C, Drabick JJ, Joshi M, Perimbeti S. Lü J, et al. Pharm Res. 2025 Jan 8. doi: 10.1007/s11095-024-03809-9. Online ahead of print. Pharm Res. 2025. PMID: 39779619
Combining with published inhibitory activity of DOH on acetylcholinesterase, agonist activity of DOH and antagonist/degrader activity of DA/D on androgen and estrogen receptors, D/DA promoting activity for glutamic acid decarboxylase (GAD)- gamma-aminobutyric acid (GABA) inhibito …
Combining with published inhibitory activity of DOH on acetylcholinesterase, agonist activity of DOH and antagonist/degrader activity of DA/ …
26,553 results
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