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NXP800 activates the unfolded protein response, altering AR and E2F function to impact castration-resistant prostate cancer growth.
Welti J, Bogdan D, Figueiredo I, Coleman I, Jiménez Vacas J, Liodaki K, Weigl F, Buroni L, Zeng W, Bernett I, Bertan C, Roumeliotis TI, Bhamra A, Rekowski J, Gurel B, Neeb AJ, Ning J, Li D, Gil VS, Riisnaes R, Miranda S, Crespo M, Ferreira A, Tunariu N, Pasqua E, Chessum N, Cheeseman M, Te Poele R, Powers M, Carreira S, Choudhary J, Clarke P, Banerji U, Swain A, Jones K, Yuan W, Workman P, Nelson PS, de Bono JS, Sharp A. Welti J, et al. Among authors: jimenez vacas j. Clin Cancer Res. 2025 Jan 9. doi: 10.1158/1078-0432.CCR-24-2386. Online ahead of print. Clin Cancer Res. 2025. PMID: 39787247
Clinical value of circulating splicing factors in prostate cancer: SRRM1 as a novel predictive biomarker and therapeutic target.
Montero-Hidalgo AJ, Gómez-Gómez E, Galán-Cañete M, Porcel-Pastrana F, Pérez-Gómez JM, Ortega-Bellido M, Carrasco-Valiente J, Chamorro-Castillo L, Campos-Hernández JP, Rangel-Zuñiga OA, González-Serrano T, Sánchez-Sánchez R, Sarmento-Cabral A, Gahete MD, Jiménez-Vacas JM, Luque RM. Montero-Hidalgo AJ, et al. Among authors: jimenez vacas jm. Mol Ther Oncol. 2024 Nov 23;32(4):200910. doi: 10.1016/j.omton.2024.200910. eCollection 2024 Dec 19. Mol Ther Oncol. 2024. PMID: 39758250 Free PMC article.
The splicing machinery is dysregulated and represents a therapeutic vulnerability in breast cancer.
Hermán-Sánchez N, G-García ME, Jiménez-Vacas JM, Yubero-Serrano EM, López-Sánchez LM, Romero-Martín S, Raya-Povedano JL, Álvarez-Benito M, Castaño JP, Luque RM, Gahete MD. Hermán-Sánchez N, et al. Among authors: jimenez vacas jm. Cell Mol Life Sci. 2024 Dec 27;82(1):18. doi: 10.1007/s00018-024-05515-6. Cell Mol Life Sci. 2024. PMID: 39725737 Free PMC article.
SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer.
Montero-Hidalgo AJ, Jiménez-Vacas JM, Gómez-Gómez E, Porcel-Pastrana F, Sáez-Martínez P, Pérez-Gómez JM, Fuentes-Fayos AC, Blázquez-Encinas R, Sánchez-Sánchez R, González-Serrano T, Castro E, López-Soto PJ, Carrasco-Valiente J, Sarmento-Cabral A, Martinez-Fuentes AJ, Eyras E, Castaño JP, Sharp A, Olmos D, Gahete MD, Luque RM. Montero-Hidalgo AJ, et al. Among authors: jimenez vacas jm. Sci Adv. 2024 Oct 4;10(40):eado8231. doi: 10.1126/sciadv.ado8231. Epub 2024 Oct 2. Sci Adv. 2024. PMID: 39356765 Free PMC article.
BCL2 expression is enriched in advanced prostate cancer with features of lineage plasticity.
Westaby D, Jiménez-Vacas JM, Figueiredo I, Rekowski J, Pettinger C, Gurel B, Lundberg A, Bogdan D, Buroni L, Neeb A, Padilha A, Taylor J, Zeng W, Das S, Hobern E, Riisnaes R, Crespo M, Miranda S, Ferreira A, Hanratty BP, Nava Rodrigues D, Bertan C, Seed G, Fenor de La Maza MLD, Guo C, Carmichael J, Grochot R, Chandran K, Stavridi A, Varkaris A, Stylianou N, Hollier BG, Tunariu N, Balk SP, Carreira S, Yuan W, Nelson PS, Corey E, Haffner M, de Bono J, Sharp A. Westaby D, et al. Among authors: jimenez vacas jm. J Clin Invest. 2024 Sep 17;134(18):e179998. doi: 10.1172/JCI179998. J Clin Invest. 2024. PMID: 39286979 Free PMC article.
Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets.
Alors-Pérez E, Blázquez-Encinas R, Moreno-Montilla MT, García-Vioque V, Jiménez-Vacas JM, Mafficini A, González-Borja I, Luchini C, Sánchez-Hidalgo JM, Sánchez-Frías ME, Pedraza-Arevalo S, Romero-Ruiz A, Lawlor RT, Viúdez A, Gahete MD, Scarpa A, Arjona-Sánchez Á, Luque RM, Ibáñez-Costa A, Castaño JP. Alors-Pérez E, et al. Among authors: jimenez vacas jm. Mol Oncol. 2024 Oct;18(10):2524-2540. doi: 10.1002/1878-0261.13658. Epub 2024 May 24. Mol Oncol. 2024. PMID: 38790138 Free PMC article.
Thio-2 Inhibits Key Signaling Pathways Required for the Development and Progression of Castration-resistant Prostate Cancer.
Neeb A, Figueiredo I, Bogdan D, Cato L, Stober J, Jiménez-Vacas JM, Gourain V, Lee II, Seeger R, Muhle-Goll C, Gurel B, Welti J, Nava Rodrigues D, Rekowski J, Qiu X, Jiang Y, Di Micco P, Mateos B, Bielskutė S, Riisnaes R, Ferreira A, Miranda S, Crespo M, Buroni L, Ning J, Carreira S, Bräse S, Jung N, Gräßle S, Swain A, Salvatella X, Plymate SR, Al-Lazikani B, Long HW, Yuan W, Brown M, Cato ACB, de Bono JS, Sharp A. Neeb A, et al. Among authors: jimenez vacas jm. Mol Cancer Ther. 2024 Jun 4;23(6):791-808. doi: 10.1158/1535-7163.MCT-23-0354. Mol Cancer Ther. 2024. PMID: 38412481 Free PMC article.
Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1.
Sáez-Martínez P, Porcel-Pastrana F, Montero-Hidalgo AJ, Lozano de la Haba S, Sanchez-Sanchez R, González-Serrano T, Gómez-Gómez E, Martínez-Fuentes AJ, Jiménez-Vacas JM, Gahete MD, Luque RM. Sáez-Martínez P, et al. Among authors: jimenez vacas jm. Cancer Lett. 2024 Mar 1;584:216604. doi: 10.1016/j.canlet.2023.216604. Epub 2024 Jan 19. Cancer Lett. 2024. PMID: 38244911 Free article.
The catalytic subunit of DNA-PK regulates transcription and splicing of AR in advanced prostate cancer.
Adamson B, Brittain N, Walker L, Duncan R, Luzzi S, Rescigno P, Smith G, McGill S, Burchmore RJ, Willmore E, Hickson I, Robson CN, Bogdan D, Jimenez-Vacas JM, Paschalis A, Welti J, Yuan W, McCracken SR, Heer R, Sharp A, de Bono JS, Gaughan L. Adamson B, et al. Among authors: jimenez vacas jm. J Clin Invest. 2023 Nov 15;133(22):e169200. doi: 10.1172/JCI169200. J Clin Invest. 2023. PMID: 37751307 Free PMC article.
Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence.
Fuentes-Fayos AC, G-García ME, Pérez-Gómez JM, Montero-Hidalgo AJ, Martín-Colom J, Doval-Rosa C, Blanco-Acevedo C, Torres E, Toledano-Delgado Á, Sánchez-Sánchez R, Peralbo-Santaella E, Ortega-Salas RM, Jiménez-Vacas JM, Tena-Sempere M, López M, Castaño JP, Gahete MD, Solivera J, Luque RM. Fuentes-Fayos AC, et al. Among authors: jimenez vacas jm. EBioMedicine. 2023 Apr;90:104484. doi: 10.1016/j.ebiom.2023.104484. Epub 2023 Mar 10. EBioMedicine. 2023. PMID: 36907105 Free PMC article.
41 results