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Page 1
Post hoc analysis of ADAMANT, a phase 2 clinical trial of active tau immunotherapy with AADvac1 in patients with Alzheimer's disease, positive for plasma p-tau217.
Kovacech B, Cullen NC, Novak P, Hanes J, Kontsekova E, Katina S, Parrak V, Fresser M, Vanbrabant J, Feldman HH, Winblad B, Stoops E, Vanmechelen E, Zilka N. Kovacech B, et al. Among authors: vanmechelen e. Alzheimers Res Ther. 2024 Nov 23;16(1):254. doi: 10.1186/s13195-024-01620-7. Alzheimers Res Ther. 2024. PMID: 39580468 Free PMC article. Clinical Trial.
Plasma pTau181 and pTau217 predict asymptomatic amyloid accumulation equally well as amyloid PET.
De Meyer S, Schaeverbeke JM, Luckett ES, Reinartz M, Blujdea ER, Cleynen I, Dupont P, Van Laere K, Vanbrabant J, Stoops E, Vanmechelen E, di Molfetta G, Zetterberg H, Ashton NJ, Teunissen CE, Poesen K, Vandenberghe R. De Meyer S, et al. Among authors: vanmechelen e. Brain Commun. 2024 May 23;6(4):fcae162. doi: 10.1093/braincomms/fcae162. eCollection 2024. Brain Commun. 2024. PMID: 39051027 Free PMC article.
Cerebrospinal fluid p-tau181, 217, and 231 in definite Creutzfeldt-Jakob disease with and without concomitant pathologies.
Emeršič A, Ashton NJ, Vrillon A, Lantero-Rodriguez J, Mlakar J, Gregorič Kramberger M, Gonzalez-Ortiz F, Kac PR, Dulewicz M, Hanrieder J, Vanmechelen E, Rot U, Zetterberg H, Karikari TK, Čučnik S, Blennow K. Emeršič A, et al. Among authors: vanmechelen e. Alzheimers Dement. 2024 Aug;20(8):5324-5337. doi: 10.1002/alz.13907. Epub 2024 Jun 24. Alzheimers Dement. 2024. PMID: 38924651 Free PMC article.
Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer's disease and a history of traumatic brain injury.
van Amerongen S, Das S, Kamps S, Goossens J, Bongers B, Pijnenburg YAL, Vanmechelen E, Vijverberg EGB, Teunissen CE, Verberk IMW. van Amerongen S, et al. Among authors: vanmechelen e. Neurobiol Aging. 2024 Sep;141:121-128. doi: 10.1016/j.neurobiolaging.2024.06.001. Epub 2024 Jun 14. Neurobiol Aging. 2024. PMID: 38908030 Free article.
The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease.
Das S, van Engelen ME, Goossens J, Jacobs D, Bongers B, Fieldhouse JLP, Pijnenburg YAL, Teunissen CE, Vanmechelen E, Verberk IMW. Das S, et al. Among authors: vanmechelen e. Alzheimers Res Ther. 2024 Feb 14;16(1):34. doi: 10.1186/s13195-024-01409-8. Alzheimers Res Ther. 2024. PMID: 38355535 Free PMC article.
Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology.
Ashton NJ, Brum WS, Di Molfetta G, Benedet AL, Arslan B, Jonaitis E, Langhough RE, Cody K, Wilson R, Carlsson CM, Vanmechelen E, Montoliu-Gaya L, Lantero-Rodriguez J, Rahmouni N, Tissot C, Stevenson J, Servaes S, Therriault J, Pascoal T, Lleó A, Alcolea D, Fortea J, Rosa-Neto P, Johnson S, Jeromin A, Blennow K, Zetterberg H. Ashton NJ, et al. Among authors: vanmechelen e. JAMA Neurol. 2024 Mar 1;81(3):255-263. doi: 10.1001/jamaneurol.2023.5319. JAMA Neurol. 2024. PMID: 38252443 Free PMC article.
Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles.
Tijms BM, Vromen EM, Mjaavatten O, Holstege H, Reus LM, van der Lee S, Wesenhagen KEJ, Lorenzini L, Vermunt L, Venkatraghavan V, Tesi N, Tomassen J, den Braber A, Goossens J, Vanmechelen E, Barkhof F, Pijnenburg YAL, van der Flier WM, Teunissen CE, Berven FS, Visser PJ. Tijms BM, et al. Among authors: vanmechelen e. Nat Aging. 2024 Jan;4(1):33-47. doi: 10.1038/s43587-023-00550-7. Epub 2024 Jan 9. Nat Aging. 2024. PMID: 38195725 Free PMC article.
Methods to Discover and Validate Biofluid-Based Biomarkers in Neurodegenerative Dementias.
Teunissen CE, Kimble L, Bayoumy S, Bolsewig K, Burtscher F, Coppens S, Das S, Gogishvili D, Fernandes Gomes B, Gómez de San José N, Mavrina E, Meda FJ, Mohaupt P, Mravinacová S, Waury K, Wojdała AL, Abeln S, Chiasserini D, Hirtz C, Gaetani L, Vermunt L, Bellomo G, Halbgebauer S, Lehmann S, Månberg A, Nilsson P, Otto M, Vanmechelen E, Verberk IMW, Willemse E, Zetterberg H; MIRIADE consortium. Teunissen CE, et al. Among authors: vanmechelen e. Mol Cell Proteomics. 2023 Oct;22(10):100629. doi: 10.1016/j.mcpro.2023.100629. Epub 2023 Aug 7. Mol Cell Proteomics. 2023. PMID: 37557955 Free PMC article.
Diagnostic accuracy of the plasma ALZpath pTau217 immunoassay to identify Alzheimer's disease pathology.
Ashton NJ, Brum WS, Di Molfetta G, Benedet AL, Arslan B, Jonatis E, Langhough RE, Cody K, Wilson R, Carlsson CM, Vanmechelen E, Montoliu-Gaya L, Lantero-Rodriguez J, Rahmouni N, Tissot C, Stevenson J, Servaes S, Therriault J, Pascoal T, Lleó A, Alcolea D, Fortea J, Rosa-Neto P, Johnson S, Jeromin A, Blennow K, Zetterberg H. Ashton NJ, et al. Among authors: vanmechelen e. medRxiv [Preprint]. 2023 Jul 12:2023.07.11.23292493. doi: 10.1101/2023.07.11.23292493. medRxiv. 2023. PMID: 37502842 Free PMC article. Preprint.
160 results