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A single-center, single-arm, prospective, open-label, and comparative trial to evaluate the safety and tolerability profile of a 90-day oral L-arginine hydrochloride intervention for patients with amyotrophic lateral sclerosis.
Naito H, Nakamori M, Toko M, Hayashi Y, Tazuma T, Watanabe T, Ishihara K, Tachiyama K, Yamazaki Y, Maruyama H. Naito H, et al. Among authors: tazuma t. Sci Rep. 2025 Jan 7;15(1):1120. doi: 10.1038/s41598-024-84944-6. Sci Rep. 2025. PMID: 39774976 Free PMC article. Clinical Trial.
A 36-year-old Man with Repeated Short-term Transient Hyperammonemia and Impaired Consciousness with a Confirmed Carbamoyl Phosphate Synthase 1 Gene Monoallelic Mutation.
Ishikawa R, Sugimoto T, Abe T, Ohno N, Tazuma T, Giga M, Naito H, Kono T, Nomura E, Hara K, Yorifuji T, Yamawaki T. Ishikawa R, et al. Among authors: tazuma t. Intern Med. 2022 May 1;61(9):1387-1392. doi: 10.2169/internalmedicine.7961-21. Epub 2021 Oct 19. Intern Med. 2022. PMID: 34670888 Free PMC article.