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An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML. Swanson OM, et al. Sci Transl Med. 2025 Jan 8;17(780):eadr2218. doi: 10.1126/scitranslmed.adr2218. Epub 2025 Jan 8. Sci Transl Med. 2025. PMID: 39772772
AIntibody: an experimentally validated in silico antibody discovery design challenge.
Erasmus MF, Spector L, Ferrara F, DiNiro R, Pohl TJ, Perea-Schmittle K, Wang W, Tessier PM, Richardson C, Turner L, Kumar S, Bedinger D, Sormanni P, Fernández-Quintero ML, Ward AB, Loeffler JR, Swanson OM, Deane CM, Raybould MIJ, Evers A, Sellmann C, Bachas S, Ruffolo J, Nastri HG, Ramesh K, Sørensen J, Croasdale-Wood R, Hijano O, Leal-Lopes C, Shahsavarian M, Qiu Y, Marcatili P, Vernet E, Akbar R, Friedensohn S, Wagner R, Kurella VB, Malhotra S, Kumar S, Kidger P, Almagro JC, Furfine E, Stanton M, Graff CP, Villalba SD, Tomszak F, Teixeira AAR, Hopkins E, Dovner M, D'Angelo S, Bradbury ARM. Erasmus MF, et al. Among authors: swanson om. Nat Biotechnol. 2024 Nov;42(11):1637-1642. doi: 10.1038/s41587-024-02469-9. Nat Biotechnol. 2024. PMID: 39496931 No abstract available.