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A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques.
Zumbrun EE, Garvey CB, Wells JB, Lynn GC, Van Tongeren SA, Steffens JT, Wetzel KS, Wetzel DL, Esham HL, Garza NL, Lee ED, Scruggs JL, Rossi FD, Brown ES, Weidner JM, Gomba LM, O'Brien KA, Jay AN, Zeng X, Akers KS, Kallgren PA, Englund E, Meinig JM, Kugelman JR, Moore JL, Bloomfield HA, Norris SL, Bryan T, Scheuerell CH, Walters J, Mollova N, Blair C, Babusis D, Cihlar T, Porter DP, Singh B, Hedskog C, Bavari S, Warren TK, Bannister R. Zumbrun EE, et al. Among authors: warren tk. Viruses. 2024 Dec 18;16(12):1934. doi: 10.3390/v16121934. Viruses. 2024. PMID: 39772240 Free PMC article.
Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus.
Warren TK, Kane CD, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Steffens J, Gomba L, Weidner JM, Norris S, Zeng X, Bannister R, Cihlar T, Bavari S, Porter DP, Iversen PL. Warren TK, et al. Sci Rep. 2021 Sep 30;11(1):19458. doi: 10.1038/s41598-021-98971-0. Sci Rep. 2021. PMID: 34593911 Free PMC article.
Recent successes in therapeutics for Ebola virus disease: no time for complacency.
Iversen PL, Kane CD, Zeng X, Panchal RG, Warren TK, Radoshitzky SR, Kuhn JH, Mudhasani RR, Cooper CL, Shurtleff AC, Nasar F, Sunay MM, Duplantier AJ, Eaton BP, Zumbrun EE, Bixler SL, Martin S, Meinig JM, Chiang CY, Sanchez-Lockhart M, Palacios GF, Kugelman JR, Martins KA, Pitt ML, Crozier I, Saunders DL. Iversen PL, et al. Among authors: warren tk. Lancet Infect Dis. 2020 Sep;20(9):e231-e237. doi: 10.1016/S1473-3099(20)30282-6. Epub 2020 Jun 18. Lancet Infect Dis. 2020. PMID: 32563280 Free PMC article. Review.
Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus.
Porter DP, Weidner JM, Gomba L, Bannister R, Blair C, Jordan R, Wells J, Wetzel K, Garza N, Van Tongeren S, Donnelly G, Steffens J, Moreau A, Bearss J, Lee E, Bavari S, Cihlar T, Warren TK. Porter DP, et al. Among authors: warren tk. J Infect Dis. 2020 Nov 9;222(11):1894-1901. doi: 10.1093/infdis/jiaa290. J Infect Dis. 2020. PMID: 32479636
Cholesterol-conjugated stapled peptides inhibit Ebola and Marburg viruses in vitro and in vivo.
Pessi A, Bixler SL, Soloveva V, Radoshitzky S, Retterer C, Kenny T, Zamani R, Gomba G, Gharabeih D, Wells J, Wetzel KS, Warren TK, Donnelly G, Van Tongeren SA, Steffens J, Duplantier AJ, Kane CD, Vicat P, Couturier V, Kester KE, Shiver J, Carter K, Bavari S. Pessi A, et al. Among authors: warren tk. Antiviral Res. 2019 Nov;171:104592. doi: 10.1016/j.antiviral.2019.104592. Epub 2019 Aug 29. Antiviral Res. 2019. PMID: 31473342 Free article.
Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison.
Ward MD, Brueggemann EE, Kenny T, Reitstetter RE, Mahone CR, Trevino S, Wetzel K, Donnelly GC, Retterer C, Norgren RB Jr, Panchal RG, Warren TK, Bavari S, Cazares LH. Ward MD, et al. Among authors: warren tk. Clin Proteomics. 2019 Feb 7;16:7. doi: 10.1186/s12014-019-9227-3. eCollection 2019. Clin Proteomics. 2019. PMID: 30774579 Free PMC article.
Persistent Marburg Virus Infection in the Testes of Nonhuman Primate Survivors.
Coffin KM, Liu J, Warren TK, Blancett CD, Kuehl KA, Nichols DK, Bearss JJ, Schellhase CW, Retterer CJ, Weidner JM, Radoshitzky SR, Brannan JM, Cardile AP, Dye JM, Palacios G, Sun MG, Kuhn JH, Bavari S, Zeng X. Coffin KM, et al. Among authors: warren tk. Cell Host Microbe. 2018 Sep 12;24(3):405-416.e3. doi: 10.1016/j.chom.2018.08.003. Epub 2018 Aug 30. Cell Host Microbe. 2018. PMID: 30173956 Free article.
52 results