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Delayed low-dose oral administration of 4'-fluorouridine inhibits pathogenic arenaviruses in animal models of lethal disease.
Welch SR, Spengler JR, Westover JB, Bailey KW, Davies KA, Aida-Ficken V, Bluemling GR, Boardman KM, Wasson SR, Mao S, Kuiper DL, Hager MW, Saindane MT, Andrews MK, Krueger RE, Sticher ZM, Jung KH, Chatterjee P, Shrivastava-Ranjan P, Lo MK, Coleman-McCray JD, Sorvillo TE, Genzer SC, Scholte FEM, Kelly JA, Jenks MH, McMullan LK, Albariño CG, Montgomery JM, Painter GR, Natchus MG, Kolykhalov AA, Gowen BB, Spiropoulou CF, Flint M. Welch SR, et al. Among authors: gowen bb. Sci Transl Med. 2024 Nov 20;16(774):eado7034. doi: 10.1126/scitranslmed.ado7034. Epub 2024 Nov 20. Sci Transl Med. 2024. PMID: 39565871
Meeting report of the 37th International Conference on Antiviral Research in Gold Coast, Australia, May 20-24, 2024, organized by the International Society for Antiviral Research.
Welch SR, Bilello JP, Carter K, Delang L, Dirr L, Durantel D, Feng JY, Gowen BB, Herrero LJ, Janeba Z, Kleymann G, Lee AA, Meier C, Moffat J, Schang LM, Schiffer JT, Seley-Radtke KL, Sheahan TP, Spengler JR. Welch SR, et al. Among authors: gowen bb. Antiviral Res. 2024 Dec;232:106037. doi: 10.1016/j.antiviral.2024.106037. Epub 2024 Nov 13. Antiviral Res. 2024. PMID: 39542140
Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine.
Westover JB, Jung KH, Alkan C, Boardman KM, Van Wettere AJ, Martens C, Rojas I, Hicks P, Thomas AJ, Saindane MT, Bluemling GR, Mao S, Kolykhalov AA, Natchus MG, Bates P, Painter GR, Ikegami T, Gowen BB. Westover JB, et al. Among authors: gowen bb. J Virol. 2024 Apr 16;98(4):e0013224. doi: 10.1128/jvi.00132-24. Epub 2024 Mar 21. J Virol. 2024. PMID: 38511932 Free PMC article.
Restoration of virulence in the attenuated Candid#1 vaccine virus requires reversion at both positions 168 and 427 in the envelope glycoprotein GPC.
Nunberg JH, Westover JB, York J, Jung KH, Bailey KW, Boardman KM, Li M, Furnell RS, Wasson SR, Murray JS, Kaundal R, Thomas AJ, Gowen BB. Nunberg JH, et al. Among authors: gowen bb. J Virol. 2024 Apr 16;98(4):e0011224. doi: 10.1128/jvi.00112-24. Epub 2024 Mar 20. J Virol. 2024. PMID: 38506509 Free PMC article.
Meeting report: 36th International Conference on Antiviral Research in Lyon, France - March 13-17, 2023.
Spengler JR, Carter K, Delang L, Durantel D, Gowen BB, Herrero LJ, Hurst B, Janeba Z, Jordan R, Luo D, Meier C, Moffat J, Rocha-Pereira J, Seley-Radtke KL, Welch SR, Schang LM. Spengler JR, et al. Among authors: gowen bb. Antiviral Res. 2023 Sep;217:105678. doi: 10.1016/j.antiviral.2023.105678. Epub 2023 Jul 24. Antiviral Res. 2023. PMID: 37494979 Free PMC article.
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