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Non-ionotropic signaling through the NMDA receptor GluN2B carboxy terminal domain drives morphological plasticity of dendritic spines and reverses fragile X phenotypes in mouse hippocampus.
Barnes SA, Thomazeau A, Finnie PSB, Heinrich MJ, Heynen AJ, Komiyama NH, Grant SGN, Menniti FS, Osterweil EK, Bear MF. Barnes SA, et al. Among authors: osterweil ek. bioRxiv [Preprint]. 2024 Dec 23:2024.12.15.628559. doi: 10.1101/2024.12.15.628559. bioRxiv. 2024. PMID: 39764032 Free PMC article. Preprint.
Key roles of C2/GAP domains in SYNGAP1-related pathophysiology.
Katsanevaki D, Till SM, Buller-Peralta I, Nawaz MS, Louros SR, Kapgal V, Tiwari S, Walsh D, Anstey NJ, Petrović NG, Cormack A, Salazar-Sanchez V, Harris A, Farnworth-Rowson W, Sutherland A, Watson TC, Dimitrov S, Jackson AD, Arkell D, Biswal S, Dissanayake KN, Mizen LAM, Perentos N, Jones MW, Cousin MA, Booker SA, Osterweil EK, Chattarji S, Wyllie DJA, Gonzalez-Sulser A, Hardt O, Wood ER, Kind PC. Katsanevaki D, et al. Among authors: osterweil ek. Cell Rep. 2024 Sep 24;43(9):114733. doi: 10.1016/j.celrep.2024.114733. Epub 2024 Sep 12. Cell Rep. 2024. PMID: 39269903 Free article.
Enhanced hippocampal LTP but normal NMDA receptor and AMPA receptor function in a rat model of CDKL5 deficiency disorder.
Simões de Oliveira L, O'Leary HE, Nawaz S, Loureiro R, Davenport EC, Baxter P, Louros SR, Dando O, Perkins E, Peltier J, Trost M, Osterweil EK, Hardingham GE, Cousin MA, Chattarji S, Booker SA, Benke TA, Wyllie DJA, Kind PC. Simões de Oliveira L, et al. Among authors: osterweil ek. Mol Autism. 2024 Jun 14;15(1):28. doi: 10.1186/s13229-024-00601-9. Mol Autism. 2024. PMID: 38877552 Free PMC article.
Excessive proteostasis contributes to pathology in fragile X syndrome.
Louros SR, Seo SS, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano MA, Muscas M, Verity NC, Wills JC, Li KW, Nolan MF, Osterweil EK. Louros SR, et al. Among authors: osterweil ek. Neuron. 2023 Feb 15;111(4):508-525.e7. doi: 10.1016/j.neuron.2022.11.012. Epub 2022 Dec 9. Neuron. 2023. PMID: 36495869 Free article.
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
Hulme H, Meikle LM, Strittmatter N, van der Hooft JJJ, Swales J, Bragg RA, Villar VH, Ormsby MJ, Barnes S, Brown SL, Dexter A, Kamat MT, Komen JC, Walker D, Milling S, Osterweil EK, MacDonald AS, Schofield CJ, Tardito S, Bunch J, Douce G, Edgar JM, Edrada-Ebel R, Goodwin RJA, Burchmore R, Wall DM. Hulme H, et al. Among authors: osterweil ek. Sci Adv. 2020 Mar 11;6(11):eaax6328. doi: 10.1126/sciadv.aax6328. eCollection 2020 Mar. Sci Adv. 2020. PMID: 32195337 Free PMC article.
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