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Spatial tumor immune heterogeneity facilitates subtype co-existence and therapy response in pancreatic cancer.
Klein L, Tu M, Krebs N, Urbach L, Grimm D, Latif MU, Penz F, Blandau A, Wu X, Samuel RD, Küffer S, Wegwitz F, Chan N, Aliar K, Vyas F, Kishore U, Hessmann E, Trumpp A, Espinet E, Papantonis A, Khokha R, Ellenrieder V, Grünwald BT, Singh SK. Klein L, et al. Among authors: espinet e. Nat Commun. 2025 Jan 6;16(1):335. doi: 10.1038/s41467-024-55330-7. Nat Commun. 2025. PMID: 39762215 Free PMC article.
TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer.
Tu M, Klein L, Espinet E, Georgomanolis T, Wegwitz F, Li X, Urbach L, Danieli-Mackay A, Küffer S, Bojarczuk K, Mizi A, Günesdogan U, Chapuy B, Gu Z, Neesse A, Kishore U, Ströbel P, Hessmann E, Hahn SA, Trumpp A, Papantonis A, Ellenrieder V, Singh SK. Tu M, et al. Among authors: espinet e. Nat Cancer. 2021 Nov;2(11):1185-1203. doi: 10.1038/s43018-021-00258-w. Epub 2021 Nov 15. Nat Cancer. 2021. PMID: 35122059
Axon guidance receptor ROBO3 modulates subtype identity and prognosis via AXL-associated inflammatory network in pancreatic cancer.
Krebs N, Klein L, Wegwitz F, Espinet E, Maurer HC, Tu M, Penz F, Küffer S, Xu X, Bohnenberger H, Cameron S, Brunner M, Neesse A, Kishore U, Hessmann E, Trumpp A, Ströbel P, Brekken RA, Ellenrieder V, Singh SK. Krebs N, et al. Among authors: espinet e. JCI Insight. 2022 Aug 22;7(16):e154475. doi: 10.1172/jci.insight.154475. JCI Insight. 2022. PMID: 35993361 Free PMC article.
HAPLN1 potentiates peritoneal metastasis in pancreatic cancer.
Wiedmann L, De Angelis Rigotti F, Vaquero-Siguero N, Donato E, Espinet E, Moll I, Alsina-Sanchis E, Bohnenberger H, Fernandez-Florido E, Mülfarth R, Vacca M, Gerwing J, Conradi LC, Ströbel P, Trumpp A, Mogler C, Fischer A, Rodriguez-Vita J. Wiedmann L, et al. Among authors: espinet e. Nat Commun. 2023 Apr 24;14(1):2353. doi: 10.1038/s41467-023-38064-w. Nat Commun. 2023. PMID: 37095087 Free PMC article.
New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting.
Hessmann E, Schneider G; 1(st) Virtual Göttingen-Munich-Marburg Pancreatic Cancer Meeting. Hessmann E, et al. Gastroenterology. 2021 Sep;161(3):785-791. doi: 10.1053/j.gastro.2021.04.082. Epub 2021 Jun 2. Gastroenterology. 2021. PMID: 34089734 Free article.
Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype.
Liffers ST, Godfrey L, Frohn L, Haeberle L, Yavas A, Vesce R, Goering W, Opitz FV, Stoecklein N, Knoefel WT, Schlitter AM, Klöppel G, Espinet E, Trumpp A, Siveke JT, Esposito I. Liffers ST, et al. Among authors: espinet e. Gut. 2023 Mar;72(3):522-534. doi: 10.1136/gutjnl-2021-326550. Epub 2022 Aug 9. Gut. 2023. PMID: 35944927 Free PMC article.
CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma.
Noll EM, Eisen C, Stenzinger A, Espinet E, Muckenhuber A, Klein C, Vogel V, Klaus B, Nadler W, Rösli C, Lutz C, Kulke M, Engelhardt J, Zickgraf FM, Espinosa O, Schlesner M, Jiang X, Kopp-Schneider A, Neuhaus P, Bahra M, Sinn BV, Eils R, Giese NA, Hackert T, Strobel O, Werner J, Büchler MW, Weichert W, Trumpp A, Sprick MR. Noll EM, et al. Among authors: espinet e. Nat Med. 2016 Mar;22(3):278-87. doi: 10.1038/nm.4038. Epub 2016 Feb 8. Nat Med. 2016. PMID: 26855150 Free PMC article.
Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors.
Djurec M, Graña O, Lee A, Troulé K, Espinet E, Cabras L, Navas C, Blasco MT, Martín-Díaz L, Burdiel M, Li J, Liu Z, Vallespinós M, Sanchez-Bueno F, Sprick MR, Trumpp A, Sainz B Jr, Al-Shahrour F, Rabadan R, Guerra C, Barbacid M. Djurec M, et al. Among authors: espinet e. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1147-E1156. doi: 10.1073/pnas.1717802115. Epub 2018 Jan 19. Proc Natl Acad Sci U S A. 2018. PMID: 29351990 Free PMC article.
35 results