Istomine R - Search Results

1

Anti-PD-1 amplifies costimulation in melanoma-infiltrating T_h1-like Foxp3⁺ regulatory T cells to alleviate local immunosuppression.

Attias M, Alvarez F, Al-Aubodah TA, Istomine R, McCallum P, Huang F, Sleiman A, Nishimura T, Del Rincón SV, Riazalhosseini Y, Piccirillo CA. Attias M, et al. Among authors: istomine r. J Immunother Cancer. 2025 Jan 6;13(1):e009435. doi: 10.1136/jitc-2024-009435. J Immunother Cancer. 2025. PMID: 39762077 Free PMC article.

2

The eIF4EBP-eIF4E axis regulates CD4⁺ T cell differentiation through modulation of T cell activation and metabolism.

Istomine R, Al-Aubodah TA, Alvarez F, Smith JA, Wagner C, Piccirillo CA. Istomine R, et al. iScience. 2023 Apr 18;26(5):106683. doi: 10.1016/j.isci.2023.106683. eCollection 2023 May 19. iScience. 2023. PMID: 37187701 Free PMC article.

3

IL-18 is required for the T_H1-adaptation of T_REG cells and the selective suppression of T_H17 responses in acute and chronic infections.

Alvarez F, Istomine R, Da Silva Lira Filho A, Al-Aubodah TA, Huang D, Okde R, Olivier M, Fritz JH, Piccirillo CA. Alvarez F, et al. Among authors: istomine r. Mucosal Immunol. 2023 Aug;16(4):462-475. doi: 10.1016/j.mucimm.2023.05.004. Epub 2023 May 13. Mucosal Immunol. 2023. PMID: 37182738 Free article.

4

ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation.

Chang J, Bouchard A, Bouklouch Y, Panneton V, Li J, Diamantopoulos N, Mohammaei S, Istomine R, Alvarez F, Piccirillo CA, Suh WK. Chang J, et al. Among authors: istomine r. J Immunol. 2022 Jul 15;209(2):301-309. doi: 10.4049/jimmunol.2100897. Epub 2022 Jun 27. J Immunol. 2022. PMID: 35760518

5

A Hemagglutinin 1 Carrying Plant-Based Virus-like Particle Vaccine Generates an Efficacious Cellular Response by Exploiting IL-1 Signaling in Both Adult and Aged Mice.

Alvarez F, Istomine R, Hendin H, Hodgins B, Pillet S, Fritz JH, Charland N, Ward BJ, Piccirillo CA. Alvarez F, et al. Among authors: istomine r. Immunohorizons. 2022 Jun 24;6(6):384-397. doi: 10.4049/immunohorizons.2200036. Immunohorizons. 2022. PMID: 35750356 Free article.

6

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3⁺ Regulatory T Cells.

Yang YH, Istomine R, Alvarez F, Al-Aubodah TA, Shi XQ, Takano T, Thornton AM, Shevach EM, Zhang J, Piccirillo CA. Yang YH, et al. Among authors: istomine r. Cell Rep. 2020 Feb 4;30(5):1515-1529.e4. doi: 10.1016/j.celrep.2020.01.002. Cell Rep. 2020. PMID: 32023466 Free PMC article.

7

Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes.

Forgetta V, Manousaki D, Istomine R, Ross S, Tessier MC, Marchand L, Li M, Qu HQ, Bradfield JP, Grant SFA, Hakonarson H; DCCT/EDIC Research Group; Paterson AD, Piccirillo C, Polychronakos C, Richards JB. Forgetta V, et al. Among authors: istomine r. Diabetes. 2020 Apr;69(4):784-795. doi: 10.2337/db19-0831. Epub 2020 Jan 31. Diabetes. 2020. PMID: 32005708 Free PMC article.

8

Sexual dimorphism and the role of estrogen in the immune microenvironment of liver metastases.

Milette S, Hashimoto M, Perrino S, Qi S, Chen M, Ham B, Wang N, Istomine R, Lowy AM, Piccirillo CA, Brodt P. Milette S, et al. Among authors: istomine r. Nat Commun. 2019 Dec 17;10(1):5745. doi: 10.1038/s41467-019-13571-x. Nat Commun. 2019. PMID: 31848339 Free PMC article.

9

The Deubiquitinating Enzyme Ubiquitin-Specific Peptidase 11 Potentiates TGF-β Signaling in CD4⁺ T Cells to Facilitate Foxp3⁺ Regulatory T and T_H17 Cell Differentiation.

Istomine R, Alvarez F, Almadani Y, Philip A, Piccirillo CA. Istomine R, et al. J Immunol. 2019 Nov 1;203(9):2388-2400. doi: 10.4049/jimmunol.1801689. Epub 2019 Sep 25. J Immunol. 2019. PMID: 31554694

10

The alarmins IL-1 and IL-33 differentially regulate the functional specialisation of Foxp3⁺ regulatory T cells during mucosal inflammation.

Alvarez F, Istomine R, Shourian M, Pavey N, Al-Aubodah TA, Qureshi S, Fritz JH, Piccirillo CA. Alvarez F, et al. Among authors: istomine r. Mucosal Immunol. 2019 May;12(3):746-760. doi: 10.1038/s41385-019-0153-5. Epub 2019 Mar 11. Mucosal Immunol. 2019. PMID: 30872761 Free article.

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