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Discovery of IRAK1/4/pan-FLT3 Kinase Inhibitors as Treatments for Acute Myeloid Leukemia.
Hoyt SB, Finocchio CJ, Croll E, Tawa GJ, Li H, Ma L, Li K, Liu L, Li R, Zhang X, Wilson K, Xu X, Shah P, Williams J, Fang Y, Bolanos LC, Gracia-Maldonado G, Kolt A, Robinson C, Free J, Edmondson EF, Difilippantonio S, Jones LM, Culver-Cochran AE, Rosenbaum JS, Starczynowski DT, Thomas CJ. Hoyt SB, et al. Among authors: edmondson ef. ACS Med Chem Lett. 2024 Oct 23;15(11):1843-1851. doi: 10.1021/acsmedchemlett.4c00269. eCollection 2024 Nov 14. ACS Med Chem Lett. 2024. PMID: 39563805 Free PMC article.
Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
Ridnour LA, Heinz WF, Cheng RYS, Wink AL, Kedei N, Pore M, Imtiaz F, Femino EL, Gonzalez AL, Coutinho LL, Moffat RL, Butcher D, Edmondson EF, Li X, Rangel MC, Kinders RJ, Rittscher J, Lipkowitz S, Wong STC, Anderson SK, McVicar DW, Glynn SA, Billiar TR, Chang JC, Hewitt SM, Ambs S, Lockett SJ, Wink DA. Ridnour LA, et al. Among authors: edmondson ef. Cancer Res Commun. 2024 Oct 1;4(10):2766-2782. doi: 10.1158/2767-9764.CRC-24-0235. Cancer Res Commun. 2024. PMID: 39356141 Free PMC article.
Transfer RNA acetylation regulates in vivo mammalian stress signaling.
Gamage ST, Khoogar R, Manage SH, Crawford MC, Georgeson J, Polevoda BV, Sanders C, Lee KA, Nance KD, Iyer V, Kustanovich A, Perez M, Thu CT, Nance SR, Amin R, Miller CN, Holewinski RJ, Meyer T, Koparde V, Yang A, Jailwala P, Nguyen JT, Andresson T, Hunter K, Gu S, Mock BA, Edmondson EF, Difilippantonio S, Chari R, Schwartz S, O'Connell MR, Chih-Chien Wu C, Meier JL. Gamage ST, et al. Among authors: edmondson ef. bioRxiv [Preprint]. 2024 Jul 28:2024.07.25.605208. doi: 10.1101/2024.07.25.605208. bioRxiv. 2024. PMID: 39091849 Free PMC article. Preprint.
Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma.
Stauffer S, Roth JS, Hernandez ER, Kowalczyk JT, Sealover NE, Hebron KE, James A, Isanogle KA, Riffle LA, Ileva L, Luo X, Chen JQ, Kedei N, Kortum RL, Lei H, Shern JF, Kalen JD, Edmondson EF, Hall MD, Difilippantonio S, Thiele CJ, Yohe ME. Stauffer S, et al. Among authors: edmondson ef. Cancers (Basel). 2024 Jun 25;16(13):2320. doi: 10.3390/cancers16132320. Cancers (Basel). 2024. PMID: 39001383 Free PMC article.
Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors.
Ridnour LA, Cheng RY, Kedei N, Somasundaram V, Bhattacharyya DD, Basudhar D, Wink AL, Walke AJ, Kim C, Heinz WF, Edmondson EF, Butcher DO, Warner AC, Dorsey TH, Pore M, Kinders RJ, Lipkowitz S, Bryant RJ, Rittscher J, Wong ST, Hewitt SM, Chang JC, Shalaby A, Callagy GM, Glynn SA, Ambs S, Anderson SK, McVicar DW, Lockett SJ, Wink DA. Ridnour LA, et al. Among authors: edmondson ef. JCI Insight. 2024 May 21;9(12):e165356. doi: 10.1172/jci.insight.165356. JCI Insight. 2024. PMID: 38912586 Free PMC article.
Spatial analysis of NOS2 and COX2 interaction with T-effector cells reveals immunosuppressive landscapes associated with poor outcome in ER- breast cancer patients.
Ridnour LA, Cheng RYS, Heinz WF, Pore M, Gonzalez AL, Femino EL, Moffat R, Wink AL, Imtiaz F, Coutinho L, Butcher D, Edmondson EF, Rangel MC, Wong STC, Lipkowitz S, Glynn S, Vitek MP, McVicar DW, Li X, Anderson SK, Paolocci N, Hewitt SM, Ambs S, Billiar TR, Chang JC, Lockett SJ, Wink DA. Ridnour LA, et al. Among authors: edmondson ef. bioRxiv [Preprint]. 2023 Dec 23:2023.12.21.572867. doi: 10.1101/2023.12.21.572867. bioRxiv. 2023. PMID: 38187660 Free PMC article. Preprint.
57 results