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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of four small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities.
Guo X, Seo JE, Xu H, Yan J, Malhi P, Atrakchi AH, Mcgovern T, Davis Bruno KL, Heflich RH, Chen T. Guo X, et al. Among authors: mcgovern t. Toxicol Sci. 2025 Jan 3:kfaf002. doi: 10.1093/toxsci/kfaf002. Online ahead of print. Toxicol Sci. 2025. PMID: 39752321
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays.
Li X, Le Y, Seo JE, Guo X, Li Y, Chen S, Mittelstaedt RA, Moore N, Guerrero S, Sims A, King ST, Atrakchi AH, McGovern TJ, Davis-Bruno KL, Keire DA, Elespuru RK, Heflich RH, Mei N. Li X, et al. Among authors: mcgovern tj. Regul Toxicol Pharmacol. 2023 Jun;141:105410. doi: 10.1016/j.yrtph.2023.105410. Epub 2023 May 18. Regul Toxicol Pharmacol. 2023. PMID: 37210026 Free PMC article.
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test.
Heflich RH, Bishop ME, Mittelstaedt RA, Yan J, Guerrero SK, Sims AM, Mitchell K, Moore N, Li X, Mei N, Elespuru RK, King ST, Keire DA, Kruhlak NL, Dorsam RT, Raw AS, Davis Bruno KL, McGovern TJ, Atrakchi AH. Heflich RH, et al. Among authors: mcgovern tj. Regul Toxicol Pharmacol. 2024 Nov;153:105709. doi: 10.1016/j.yrtph.2024.105709. Epub 2024 Sep 28. Regul Toxicol Pharmacol. 2024. PMID: 39343352
ICH S1 prospective evaluation study: weight of evidence approach to predict outcome and value of 2-year rat carcinogenicity studies. A report from the regulatory authorities subgroup.
Bourcier T, McGovern T, Cavaliero T, Ebere G, Nishikawa A, Nishimura J, Ogawa K, Pasanen M, Vespa A, Van der Laan JW. Bourcier T, et al. Among authors: mcgovern t. Front Toxicol. 2024 Apr 11;6:1353783. doi: 10.3389/ftox.2024.1353783. eCollection 2024. Front Toxicol. 2024. PMID: 38665214 Free PMC article.
Determining recommended acceptable intake limits for N-nitrosamine impurities in pharmaceuticals: Development and application of the Carcinogenic Potency Categorization Approach (CPCA).
Kruhlak NL, Schmidt M, Froetschl R, Graber S, Haas B, Horne I, Horne S, King ST, Koval IA, Kumaran G, Langenkamp A, McGovern TJ, Peryea T, Sanh A, Siqueira Ferreira A, van Aerts L, Vespa A, Whomsley R. Kruhlak NL, et al. Among authors: mcgovern tj. Regul Toxicol Pharmacol. 2024 Jun;150:105640. doi: 10.1016/j.yrtph.2024.105640. Epub 2024 May 14. Regul Toxicol Pharmacol. 2024. PMID: 38754805 Free article.
244 results