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254 results

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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of four small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities.
Guo X, Seo JE, Xu H, Yan J, Malhi P, Atrakchi AH, Mcgovern T, Davis Bruno KL, Heflich RH, Chen T. Guo X, et al. Among authors: heflich rh. Toxicol Sci. 2025 Jan 3:kfaf002. doi: 10.1093/toxsci/kfaf002. Online ahead of print. Toxicol Sci. 2025. PMID: 39752321
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test.
Heflich RH, Bishop ME, Mittelstaedt RA, Yan J, Guerrero SK, Sims AM, Mitchell K, Moore N, Li X, Mei N, Elespuru RK, King ST, Keire DA, Kruhlak NL, Dorsam RT, Raw AS, Davis Bruno KL, McGovern TJ, Atrakchi AH. Heflich RH, et al. Regul Toxicol Pharmacol. 2024 Nov;153:105709. doi: 10.1016/j.yrtph.2024.105709. Epub 2024 Sep 28. Regul Toxicol Pharmacol. 2024. PMID: 39343352
Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations.
Wang Y, Le Y, Harris KL, Chen Y, Li X, Faske J, Wynne RA, Mittelstaedt RA, Cao X, Miranda-Colon J, Elkins L, Muskhelishvili L, Davis K, Mei N, Sun W, Robison TW, Heflich RH, Parsons BL. Wang Y, et al. Among authors: heflich rh. Mutat Res Genet Toxicol Environ Mutagen. 2024 Jul;897:503786. doi: 10.1016/j.mrgentox.2024.503786. Epub 2024 Jun 24. Mutat Res Genet Toxicol Environ Mutagen. 2024. PMID: 39054009
Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT).
Parsons BL, Beal MA, Dearfield KL, Douglas GR, Gi M, Gollapudi BB, Heflich RH, Horibata K, Kenyon M, Long AS, Lovell DP, Lynch AM, Myers MB, Pfuhler S, Vespa A, Zeller A, Johnson GE, White PA. Parsons BL, et al. Among authors: heflich rh. Environ Mol Mutagen. 2024 Jun 3. doi: 10.1002/em.22599. Online ahead of print. Environ Mol Mutagen. 2024. PMID: 38828778 Review.
Interpretation of in vitro concentration-response data for risk assessment and regulatory decision-making: Report from the 2022 IWGT quantitative analysis expert working group meeting.
Beal MA, Chen G, Dearfield KL, Gi M, Gollapudi B, Heflich RH, Horibata K, Long AS, Lovell DP, Parsons BL, Pfuhler S, Wills J, Zeller A, Johnson G, White PA. Beal MA, et al. Among authors: heflich rh. Environ Mol Mutagen. 2023 Dec 19. doi: 10.1002/em.22582. Online ahead of print. Environ Mol Mutagen. 2023. PMID: 38115239 Review.
Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.
Marchetti F, Cardoso R, Chen CL, Douglas GR, Elloway J, Escobar PA, Harper T Jr, Heflich RH, Kidd D, Lynch AM, Myers MB, Parsons BL, Salk JJ, Settivari RS, Smith-Roe SL, Witt KL, Yauk CL, Young R, Zhang S, Minocherhomji S. Marchetti F, et al. Among authors: heflich rh. Mutat Res Rev Mutat Res. 2023 Jul-Dec;792:108466. doi: 10.1016/j.mrrev.2023.108466. Epub 2023 Aug 27. Mutat Res Rev Mutat Res. 2023. PMID: 37643677 Free article. Review.
254 results