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Page 1
Imagine, Discover, Inspire: Proceedings of the 4th International Conference of the Trisomy 21 Research Society.
Flores-Aguilar L, Hamlett ED, Araya P, Barone E, Bhattacharyya A, Carmona-Iragui M, Chan L, Christian B, Costa ACS, Costanzo F, Del Hoyo Soriano L, Dierssen M, Eichler EE, Fisher E, Galbraith M, Ghosh S, Gimenez S, Guedj F, Guidi S, Iulita MF, Mobley W, Pelleri MC, Potier MC, Rabin KR, Rachubinski A, Rebillat AS, Rubenstein E, Saternos H, Sordo L, Strydom A, Valle-Tamayo N, Waugh KA, Yu E, Zeldich E, Busciglio J, Head E. Flores-Aguilar L, et al. Among authors: head e. Neuromolecular Med. 2025 Jan 5;27(1):5. doi: 10.1007/s12017-024-08824-y. Neuromolecular Med. 2025. PMID: 39756004
The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers.
McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT. McLachlan M, et al. Among authors: head e. medRxiv [Preprint]. 2024 Dec 6:2024.12.04.24318526. doi: 10.1101/2024.12.04.24318526. medRxiv. 2024. PMID: 39677434 Free PMC article. Preprint.
Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.
Dutt S, Bachman SL, Dahl MJ, Li Y, Yew B, Jang JY, Ho JK, Nashiro K, Min J, Yoo HJ, Gaubert A, Nguyen A, Blanken AE, Sible IJ, Marshall AJ, Kapoor A, Alitin JPM, Hoang K, Rouanet J, Sordo L, Head E, Shao X, Wang DJJ, Mather M, Nation DA. Dutt S, et al. Among authors: head e. Neurobiol Aging. 2024 Nov 27;147:12-21. doi: 10.1016/j.neurobiolaging.2024.11.008. Online ahead of print. Neurobiol Aging. 2024. PMID: 39637519
Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's disease.
Miyoshi E, Morabito S, Henningfield CM, Das S, Rahimzadeh N, Shabestari SK, Michael N, Emerson N, Reese F, Shi Z, Cao Z, Srinivasan SS, Scarfone VM, Arreola MA, Lu J, Wright S, Silva J, Leavy K, Lott IT, Doran E, Yong WH, Shahin S, Perez-Rosendahl M; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC–DS); Head E, Green KN, Swarup V. Miyoshi E, et al. Among authors: head e. Nat Genet. 2024 Dec;56(12):2704-2717. doi: 10.1038/s41588-024-01961-x. Epub 2024 Nov 22. Nat Genet. 2024. PMID: 39578645 Free PMC article.
Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Schworer EK, et al. Among authors: head e. Lancet Neurol. 2024 Dec;23(12):1214-1224. doi: 10.1016/S1474-4422(24)00426-5. Lancet Neurol. 2024. PMID: 39577922
Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.
Engstrom AC, Alitin JPM, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJJ, Nation DA. Engstrom AC, et al. Among authors: head e. Alzheimers Dement. 2024 Nov 18. doi: 10.1002/alz.14396. Online ahead of print. Alzheimers Dement. 2024. PMID: 39555916
Calcineurin/NFAT inhibitors maintain cognition in a preclinical prevention study in an aging canine model of Alzheimer disease.
Sordo L, Ubele MF, Boaz KA, Mefford JL, Jones ED, McCarty KL, van Rooyen HY, Smiley J, Bembenek Bailey SA, Perpich JA, Meacham B, Powell DK, Bresch F, Crump JW, Phelan MJ, Noche JA, Stark CE, Puskás LG, Norris CM, Head E. Sordo L, et al. Among authors: head e. Neurobiol Aging. 2025 Feb;146:1-14. doi: 10.1016/j.neurobiolaging.2024.11.003. Epub 2024 Nov 10. Neurobiol Aging. 2025. PMID: 39547056
The mediating role of plasma glial fibrillary acidic protein in amyloid and tau pathology in Down's syndrome.
Boerwinkle AH, Wisch JK, Handen BL, Head E, Mapstone M, Rafii MS, O'Bryant SE, Krinsky-McHale SJ, Lai F, Rosas HD, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Ances BM; Alzheimer's Biomarker Consortium‐Down Syndrome. Boerwinkle AH, et al. Among authors: head e. Alzheimers Dement. 2024 Nov 13. doi: 10.1002/alz.14359. Online ahead of print. Alzheimers Dement. 2024. PMID: 39535359
401 results