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Visium spatial transcriptomics and proteomics identifies novel hepatic cell populations and transcriptomic signatures of alcohol-associated hepatitis.
Gripshover TC, Treves RS, Rouchka EC, Chariker JH, Zheng S, Hudson E, Smith ML, Singal AK, McClain CJ, Hardesty JE. Gripshover TC, et al. Among authors: mcclain cj. Alcohol Clin Exp Res (Hoboken). 2024 Nov 26. doi: 10.1111/acer.15494. Online ahead of print. Alcohol Clin Exp Res (Hoboken). 2024. PMID: 39592394
Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3×Tg-AD mice.
Chilton PM, Ghare SS, Charpentier BT, Myers SA, Rao AV, Petrosino JF, Hoffman KL, Greenwell JC, Tyagi N, Behera J, Wang Y, Sloan LJ, Zhang J, Shields CB, Cooper GE, Gobejishvili L, Whittemore SR, McClain CJ, Barve SS. Chilton PM, et al. Among authors: mcclain cj. Gut Microbes. 2024 Jan-Dec;16(1):2389319. doi: 10.1080/19490976.2024.2389319. Epub 2024 Aug 25. Gut Microbes. 2024. PMID: 39182227 Free PMC article.
In vivo Bruton's tyrosine kinase inhibition attenuates alcohol-associated liver disease by regulating CD84-mediated granulopoiesis.
Nagesh PT, Cho Y, Zhuang Y, Babuta M, Ortega-Ribera M, Joshi R, Brezani V, Patel A, Datta AA, Brezani V, Hsieh YC, Ramos A, Mehta J, Copeland C, Kanata E, Jiang ZG, Vlachos I, Asara J; AlcHepNet Consortium; Szabo G. Nagesh PT, et al. Sci Transl Med. 2024 Aug 7;16(759):eadg1915. doi: 10.1126/scitranslmed.adg1915. Epub 2024 Aug 7. Sci Transl Med. 2024. PMID: 39110779
464 results