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A surrogate ELISA to select high titer human convalescent plasma for treating immunocompromised patients infected with SARS-CoV-2 variants of concern.
Dolange V, Slamanig S, Abdeljawad A, Ying TL, Lemus N, Singh G, Carreño JM, Abad A, Srivastava K, Simon V, Sachithanandham J, Pekosz A, Sullivan D, Krammer F, Sun W, Palese P, González-Domínguez I. Dolange V, et al. Among authors: pekosz a. J Infect Dis. 2025 Jan 3:jiae645. doi: 10.1093/infdis/jiae645. Online ahead of print. J Infect Dis. 2025. PMID: 39749487
SARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma Donors.
Benner SE, Patel EU, Laeyendecker O, Pekosz A, Littlefield K, Eby Y, Fernandez RE, Miller J, Kirby CS, Keruly M, Klock E, Baker OR, Schmidt HA, Shrestha R, Burgess I, Bonny TS, Clarke W, Caturegli P, Sullivan D, Shoham S, Quinn TC, Bloch EM, Casadevall A, Tobian AAR, Redd AD. Benner SE, et al. Among authors: pekosz a. J Infect Dis. 2020 Nov 13;222(12):1974-1984. doi: 10.1093/infdis/jiaa581. J Infect Dis. 2020. PMID: 32910175 Free PMC article.
Defining the risk of SARS-CoV-2 variants on immune protection.
DeGrace MM, Ghedin E, Frieman MB, Krammer F, Grifoni A, Alisoltani A, Alter G, Amara RR, Baric RS, Barouch DH, Bloom JD, Bloyet LM, Bonenfant G, Boon ACM, Boritz EA, Bratt DL, Bricker TL, Brown L, Buchser WJ, Carreño JM, Cohen-Lavi L, Darling TL, Davis-Gardner ME, Dearlove BL, Di H, Dittmann M, Doria-Rose NA, Douek DC, Drosten C, Edara VV, Ellebedy A, Fabrizio TP, Ferrari G, Fischer WM, Florence WC, Fouchier RAM, Franks J, García-Sastre A, Godzik A, Gonzalez-Reiche AS, Gordon A, Haagmans BL, Halfmann PJ, Ho DD, Holbrook MR, Huang Y, James SL, Jaroszewski L, Jeevan T, Johnson RM, Jones TC, Joshi A, Kawaoka Y, Kercher L, Koopmans MPG, Korber B, Koren E, Koup RA, LeGresley EB, Lemieux JE, Liebeskind MJ, Liu Z, Livingston B, Logue JP, Luo Y, McDermott AB, McElrath MJ, Meliopoulos VA, Menachery VD, Montefiori DC, Mühlemann B, Munster VJ, Munt JE, Nair MS, Netzl A, Niewiadomska AM, O'Dell S, Pekosz A, Perlman S, Pontelli MC, Rockx B, Rolland M, Rothlauf PW, Sacharen S, Scheuermann RH, Schmidt SD, Schotsaert M, Schultz-Cherry S, Seder RA, Sedova M, Sette A, Shabman RS, Shen X, Shi PY, Shukla M, Simon V, Stumpf S, Sullivan NJ, Thackray LB, Theiler J, Thomas PG, Trifkovic S, Türeli … See abstract for full author list ➔ DeGrace MM, et al. Among authors: pekosz a. Nature. 2022 May;605(7911):640-652. doi: 10.1038/s41586-022-04690-5. Epub 2022 Mar 31. Nature. 2022. PMID: 35361968 Free PMC article. Review.
Spike-protein proteolytic antibodies in COVID-19 convalescent plasma contribute to SARS-CoV-2 neutralization.
McConnell SA, Sachithanandham J, Mudrak NJ, Zhu X, Farhang PA, Cordero RJB, Wear MP, Shapiro JR, Park HS, Klein SL, Tobian AAR, Bloch EM, Sullivan DJ, Pekosz A, Casadevall A. McConnell SA, et al. Among authors: pekosz a. Cell Chem Biol. 2023 Jul 20;30(7):726-738.e4. doi: 10.1016/j.chembiol.2023.05.011. Epub 2023 Jun 23. Cell Chem Biol. 2023. PMID: 37354908 Free PMC article.
SARS-CoV-2 Variants from Long-Term, Persistently Infected Immunocompromised Patients Have Altered Syncytia Formation, Temperature-Dependent Replication, and Serum Neutralizing Antibody Escape.
Wouters C, Sachithanandham J, Akin E, Pieterse L, Fall A, Truong TT, Bard JD, Yee R, Sullivan DJ, Mostafa HH, Pekosz A. Wouters C, et al. Among authors: pekosz a. Viruses. 2024 Sep 9;16(9):1436. doi: 10.3390/v16091436. Viruses. 2024. PMID: 39339912 Free PMC article.
Infection With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated With Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals.
Huai Luo C, Paul Morris C, Sachithanandham J, Amadi A, Gaston DC, Li M, Swanson NJ, Schwartz M, Klein EY, Pekosz A, Mostafa HH. Huai Luo C, et al. Among authors: pekosz a. Clin Infect Dis. 2022 Aug 24;75(1):e715-e725. doi: 10.1093/cid/ciab986. Clin Infect Dis. 2022. PMID: 34922338 Free PMC article.
Cytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent Plasma.
Bonny TS, Patel EU, Zhu X, Bloch EM, Grabowski MK, Abraham AG, Littlefield K, Shrestha R, Benner SE, Laeyendecker O, Shoham S, Sullivan D, Quinn TC, Casadevall A, Pekosz A, Redd AD, Tobian AAR. Bonny TS, et al. Among authors: pekosz a. Open Forum Infect Dis. 2020 Nov 26;8(2):ofaa574. doi: 10.1093/ofid/ofaa574. eCollection 2021 Feb. Open Forum Infect Dis. 2020. PMID: 33553467 Free PMC article.
Omicron Subvariants: Clinical, Laboratory, and Cell Culture Characterization.
Morris CP, Eldesouki RE, Sachithanandham J, Fall A, Norton JM, Abdullah O, Gallagher N, Li M, Pekosz A, Klein EY, Mostafa HH. Morris CP, et al. Among authors: pekosz a. Clin Infect Dis. 2023 Apr 3;76(7):1276-1284. doi: 10.1093/cid/ciac885. Clin Infect Dis. 2023. PMID: 36366857 Free PMC article.
Adaptive immune responses in vaccinated patients with symptomatic SARS-CoV-2 Alpha infection.
Park HS, Shapiro JR, Sitaras I, Woldemeskel BA, Garliss CC, Dziedzic A, Sachithanandham J, Jedlicka AE, Caputo CA, Rousseau KE, Thakar M, Suwanmanee S, Hauk P, Aliyu L, Majewska NI, Koley S, Patel B, Broderick P, Mosnaim G, Heath SL, Spivak ES, Shenoy A, Bloch EM, Gniadek TJ, Shoham S, Casadevall A, Hanley D, Cox AL, Laeyendecker O, Betenbaugh MJ, Cramer SM, Mostafa HH, Pekosz A, Blankson JN, Klein SL, Tobian AA, Sullivan D, Gebo KA. Park HS, et al. Among authors: pekosz a. JCI Insight. 2022 Mar 8;7(5):e155944. doi: 10.1172/jci.insight.155944. JCI Insight. 2022. PMID: 35104245 Free PMC article.
306 results