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Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration.
Bouwman M, de Bakker DEM, Honkoop H, Giovou AE, Versteeg D, Boender AR, Nguyen PD, Slotboom M, Colquhoun D, Vigil-Garcia M, Kooijman L, Janssen R, Hooijkaas IB, Günthel M, Visser KJ, Klerk M, Zentilin L, Giacca M, Kaslin J, Boink GJJ, van Rooij E, Christoffels VM, Bakkers J. Bouwman M, et al. Among authors: christoffels vm. Nat Cardiovasc Res. 2025 Jan 2. doi: 10.1038/s44161-024-00588-9. Online ahead of print. Nat Cardiovasc Res. 2025. PMID: 39747457
A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand.
Walsh R, Mauleekoonphairoj J, Mengarelli I, Bosada FM, Verkerk AO, van Duijvenboden K, Poovorawan Y, Wongcharoen W, Sutjaporn B, Wandee P, Chimparlee N, Chokesuwattanaskul R, Vongpaisarnsin K, Dangkao P, Wu CI, Tadros R, Amin AS, Lieve KVV, Postema PG, Kooyman M, Beekman L, Sahasatas D, Amnueypol M, Krittayaphong R, Prechawat S, Anannab A, Makarawate P, Ngarmukos T, Phusanti K, Veerakul G, Kingsbury Z, Newington T, Maheswari U, Ross MT, Grace A, Lambiase PD, Behr ER, Schott JJ, Redon R, Barc J, Christoffels VM, Wilde AAM, Nademanee K, Bezzina CR, Khongphatthanayothin A. Walsh R, et al. Among authors: christoffels vm. Circulation. 2025 Jan 7;151(1):31-44. doi: 10.1161/CIRCULATIONAHA.124.069041. Epub 2024 Oct 11. Circulation. 2025. PMID: 39391988 Free PMC article.
Development of the Cardiac Conduction System.
van der Maarel LE, Christoffels VM. van der Maarel LE, et al. Among authors: christoffels vm. Adv Exp Med Biol. 2024;1441:185-200. doi: 10.1007/978-3-031-44087-8_10. Adv Exp Med Biol. 2024. PMID: 38884712
TAD boundary deletion causes PITX2-related cardiac electrical and structural defects.
Baudic M, Murata H, Bosada FM, Melo US, Aizawa T, Lindenbaum P, van der Maarel LE, Guedon A, Baron E, Fremy E, Foucal A, Ishikawa T, Ushinohama H, Jurgens SJ, Choi SH, Kyndt F, Le Scouarnec S, Wakker V, Thollet A, Rajalu A, Takaki T, Ohno S, Shimizu W, Horie M, Kimura T, Ellinor PT, Petit F, Dulac Y, Bru P, Boland A, Deleuze JF, Redon R, Le Marec H, Le Tourneau T, Gourraud JB, Yoshida Y, Makita N, Vieyres C, Makiyama T, Mundlos S, Christoffels VM, Probst V, Schott JJ, Barc J. Baudic M, et al. Among authors: christoffels vm. Nat Commun. 2024 Apr 20;15(1):3380. doi: 10.1038/s41467-024-47739-x. Nat Commun. 2024. PMID: 38643172 Free PMC article.
TGFBR1 Variants Can Associate with Non-Syndromic Congenital Heart Disease without Aortopathy.
Alaamery M, Albesher N, Alhabshan F, Barnett P, Salim Kabbani M, Chaikhouni F, Ilgun A, Mook ORF, Alsaif H, Christoffels VM, van Tintelen P, Wilde AAM, Houweling AC, Massadeh S, Postma AV. Alaamery M, et al. Among authors: christoffels vm. J Cardiovasc Dev Dis. 2023 Nov 9;10(11):455. doi: 10.3390/jcdd10110455. J Cardiovasc Dev Dis. 2023. PMID: 37998513 Free PMC article.
Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice.
Lakin R, Polidovitch N, Yang S, Parikh M, Liu X, Debi R, Gao X, Chen W, Guzman C, Yakobov S, Izaddoustdar F, Wauchop M, Lei Q, Xu W, Nedospasov SA, Christoffels VM, Backx PH. Lakin R, et al. Among authors: christoffels vm. Cardiovasc Res. 2023 Dec 19;119(16):2607-2622. doi: 10.1093/cvr/cvad144. Cardiovasc Res. 2023. PMID: 37713664 Free PMC article.
229 results