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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity.
Freire-Agulleiro Ó, Estévez-Salguero Á, Ferreira V, Holleman CL, García-Currás J, González-García I, Nogueiras R, Tena-Sempere M, García-Cáceres C, Diéguez C, López M. Freire-Agulleiro Ó, et al. Among authors: garcia caceres c. Mol Metab. 2024 Dec 31;92:102091. doi: 10.1016/j.molmet.2024.102091. Online ahead of print. Mol Metab. 2024. PMID: 39746605 Free article.
Small extracellular vesicle-mediated targeting of hypothalamic AMPKα1 corrects obesity through BAT activation.
Milbank E, Dragano NRV, González-García I, Garcia MR, Rivas-Limeres V, Perdomo L, Hilairet G, Ruiz-Pino F, Mallegol P, Morgan DA, Iglesias-Rey R, Contreras C, Vergori L, Cuñarro J, Porteiro B, Gavaldà-Navarro A, Oelkrug R, Vidal A, Roa J, Sobrino T, Villarroya F, Diéguez C, Nogueiras R, García-Cáceres C, Tena-Sempere M, Mittag J, Carmen Martínez M, Rahmouni K, Andriantsitohaina R, López M. Milbank E, et al. Nat Metab. 2021 Oct;3(10):1415-1431. doi: 10.1038/s42255-021-00467-8. Epub 2021 Oct 21. Nat Metab. 2021. PMID: 34675439
Astrocytic GABA in LHA is an obesity 'thermostat'.
González-García I, García-Cáceres C. González-García I, et al. Nat Metab. 2023 Sep;5(9):1454-1455. doi: 10.1038/s42255-023-00849-0. Nat Metab. 2023. PMID: 37653042 No abstract available.
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.
Contreras RE, Gruber T, González-García I, Schriever SC, De Angelis M, Mallet N, Bernecker M, Legutko B, Kabra D, Schmidt M, Tschöp MH, Gutierrez-Aguilar R, Mellor J, García-Cáceres C, Pfluger PT. Contreras RE, et al. Among authors: garcia caceres c. Mol Metab. 2024 Dec;90:102033. doi: 10.1016/j.molmet.2024.102033. Epub 2024 Sep 19. Mol Metab. 2024. PMID: 39304061 Free PMC article.
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.
Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R. Quiñones M, et al. Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6. Nat Commun. 2018. PMID: 30143607 Free PMC article.
Synaptotagmin-13 Is a Neuroendocrine Marker in Brain, Intestine and Pancreas.
Tarquis-Medina M, Scheibner K, González-García I, Bastidas-Ponce A, Sterr M, Jaki J, Schirge S, García-Cáceres C, Lickert H, Bakhti M. Tarquis-Medina M, et al. Int J Mol Sci. 2021 Nov 20;22(22):12526. doi: 10.3390/ijms222212526. Int J Mol Sci. 2021. PMID: 34830411 Free PMC article.
Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1.
González-García I, García-Clavé E, Cebrian-Serrano A, Le Thuc O, Contreras RE, Xu Y, Gruber T, Schriever SC, Legutko B, Lintelmann J, Adamski J, Wurst W, Müller TD, Woods SC, Pfluger PT, Tschöp MH, Fisette A, García-Cáceres C. González-García I, et al. Cell Metab. 2023 Mar 7;35(3):438-455.e7. doi: 10.1016/j.cmet.2023.02.004. Cell Metab. 2023. PMID: 36889283 Free PMC article.
79 results