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Page 1
Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains.
Bryan E, Valsakumar D, Idigo NJ, Warburton M, Webb KM, McLaughlin KA, Spanos C, Lenci S, Major V, Ambrosi C, Andrews S, Baubec T, Rappsilber J, Voigt P. Bryan E, et al. Among authors: valsakumar d. Mol Cell. 2024 Dec 20:S1097-2765(24)00997-3. doi: 10.1016/j.molcel.2024.12.002. Online ahead of print. Mol Cell. 2024. PMID: 39731917 Free article.
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar H, Clifford G, Rolls W, Pasquier M, Burdett H, Zhang Y, Deák G, Zou J, Spanos C, Taylor MRD, Mills J, Watson JA, Kumar D, Clark R, Das A, Valsakumar D, Bramham J, Voigt P, Sproul D, Wilson MD. Wapenaar H, et al. Among authors: valsakumar d. EMBO Rep. 2024 Dec;25(12):5743-5779. doi: 10.1038/s44319-024-00306-3. Epub 2024 Nov 11. EMBO Rep. 2024. PMID: 39528729 Free PMC article.
Two-factor authentication underpins the precision of the piRNA pathway.
Dias Mirandela M, Zoch A, Leismann J, Webb S, Berrens RV, Valsakumar D, Kabayama Y, Auchynnikava T, Schito M, Chowdhury T, MacLeod D, Xiang X, Zou J, Rappsilber J, Allshire RC, Voigt P, Cook AG, Barau J, O'Carroll D. Dias Mirandela M, et al. Among authors: valsakumar d. Nature. 2024 Oct;634(8035):979-985. doi: 10.1038/s41586-024-07963-3. Epub 2024 Sep 18. Nature. 2024. PMID: 39294378 Free PMC article.
The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
Davarinejad H, Huang YC, Mermaz B, LeBlanc C, Poulet A, Thomson G, Joly V, Muñoz M, Arvanitis-Vigneault A, Valsakumar D, Villarino G, Ross A, Rotstein BH, Alarcon EI, Brunzelle JS, Voigt P, Dong J, Couture JF, Jacob Y. Davarinejad H, et al. Among authors: valsakumar d. Science. 2022 Mar 18;375(6586):1281-1286. doi: 10.1126/science.abm5320. Epub 2022 Mar 17. Science. 2022. PMID: 35298257 Free PMC article.
A coherent feed-forward loop drives vascular regeneration in damaged aerial organs of plants growing in a normal developmental context.
Radhakrishnan D, Shanmukhan AP, Kareem A, Aiyaz M, Varapparambathu V, Toms A, Kerstens M, Valsakumar D, Landge AN, Shaji A, Mathew MK, Sawchuk MG, Scarpella E, Krizek BA, Efroni I, Mähönen AP, Willemsen V, Scheres B, Prasad K. Radhakrishnan D, et al. Among authors: valsakumar d. Development. 2020 Mar 30;147(6):dev185710. doi: 10.1242/dev.185710. Development. 2020. PMID: 32108025