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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting.
Lim K, Kan WL, Nair PC, Kutyna M, Lopez AF, Hercus T, Ross DM, Lane S, Fong CY, Brown A, Yong A, Yeung D, Hughes T, Hiwase D, Thomas D. Lim K, et al. Among authors: kan wl. PLoS One. 2024 Sep 19;19(9):e0310641. doi: 10.1371/journal.pone.0310641. eCollection 2024. PLoS One. 2024. PMID: 39298477 Free PMC article. Clinical Trial.
Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.
Kan WL, Dhagat U, Kaufmann KB, Hercus TR, Nero TL, Zeng AGX, Toubia J, Barry EF, Broughton SE, Gomez GA, Benard BA, Dottore M, Cheung Tung Shing KS, Boutzen H, Samaraweera SE, Simpson KJ, Jin L, Goodall GJ, Begley CG, Thomas D, Ekert PG, Tvorogov D, D'Andrea RJ, Dick JE, Parker MW, Lopez AF. Kan WL, et al. Cancer Discov. 2023 Aug 4;13(8):1922-1947. doi: 10.1158/2159-8290.CD-22-1396. Cancer Discov. 2023. PMID: 37191437 Free PMC article.
Messing with βc: A unique receptor with many goals.
Kan WL, Cheung Tung Shing KS, Nero TL, Hercus TR, Tvorogov D, Parker MW, Lopez AF. Kan WL, et al. Semin Immunol. 2021 Apr;54:101513. doi: 10.1016/j.smim.2021.101513. Epub 2021 Nov 24. Semin Immunol. 2021. PMID: 34836771 Review.
Accumulation of JAK activation loop phosphorylation is linked to type I JAK inhibitor withdrawal syndrome in myelofibrosis.
Tvorogov D, Thomas D, Liau NPD, Dottore M, Barry EF, Lathi M, Kan WL, Hercus TR, Stomski F, Hughes TP, Tergaonkar V, Parker MW, Ross DM, Majeti R, Babon JJ, Lopez AF. Tvorogov D, et al. Among authors: kan wl. Sci Adv. 2018 Nov 28;4(11):eaat3834. doi: 10.1126/sciadv.aat3834. eCollection 2018 Nov. Sci Adv. 2018. PMID: 30498775 Free PMC article.
A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Broughton SE, Hercus TR, Nero TL, Kan WL, Barry EF, Dottore M, Cheung Tung Shing KS, Morton CJ, Dhagat U, Hardy MP, Wilson NJ, Downton MT, Schieber C, Hughes TP, Lopez AF, Parker MW. Broughton SE, et al. Among authors: kan wl. Nat Commun. 2018 Jan 26;9(1):386. doi: 10.1038/s41467-017-02633-7. Nat Commun. 2018. PMID: 29374162 Free PMC article.
Role of the β Common (βc) Family of Cytokines in Health and Disease.
Hercus TR, Kan WLT, Broughton SE, Tvorogov D, Ramshaw HS, Sandow JJ, Nero TL, Dhagat U, Thompson EJ, Shing KSCT, McKenzie DR, Wilson NJ, Owczarek CM, Vairo G, Nash AD, Tergaonkar V, Hughes T, Ekert PG, Samuel MS, Bonder CS, Grimbaldeston MA, Parker MW, Lopez AF. Hercus TR, et al. Among authors: kan wlt. Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6):a028514. doi: 10.1101/cshperspect.a028514. Cold Spring Harb Perspect Biol. 2018. PMID: 28716883 Free PMC article. Review.
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