Wang S - Search Results

1

A patent review of xanthine oxidase inhibitors (2021-present).

Liu C, Mao Q, Zhang B, Fu X, Zhang T, Wang S. Liu C, et al. Among authors: wang s. Expert Opin Ther Pat. 2024 Dec 28. doi: 10.1080/13543776.2024.2446222. Online ahead of print. Expert Opin Ther Pat. 2024. PMID: 39731464 Review.

2

Intramolecular hydrogen bond interruption and scaffold hopping of TMC-5 led to 2-(4-alkoxy-3-cyanophenyl)pyrimidine-4/5-carboxylic acids and 6-(4-alkoxy-3-cyanophenyl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-ones as potent pyrimidine-based xanthine oxidase inhibitors.

Zhao J, Mao Q, Lin F, Zhang B, Sun M, Zhang T, Wang S. Zhao J, et al. Among authors: wang s. Eur J Med Chem. 2022 Feb 5;229:114086. doi: 10.1016/j.ejmech.2021.114086. Epub 2021 Dec 29. Eur J Med Chem. 2022. PMID: 34992040

3

Synthesis of some 5-phenylisoxazole-3-carboxylic acid derivatives as potent xanthine oxidase inhibitors.

Wang S, Yan J, Wang J, Chen J, Zhang T, Zhao Y, Xue M. Wang S, et al. Among authors: wang j. Eur J Med Chem. 2010 Jun;45(6):2663-70. doi: 10.1016/j.ejmech.2010.02.013. Epub 2010 Feb 10. Eur J Med Chem. 2010. PMID: 20189693

4

Synthesis and evaluation of 1-hydroxy/methoxy-4-methyl-2-phenyl-1H-imidazole-5-carboxylic acid derivatives as non-purine xanthine oxidase inhibitors.

Chen S, Zhang T, Wang J, Wang F, Niu H, Wu C, Wang S. Chen S, et al. Among authors: wang f, wang j, wang s. Eur J Med Chem. 2015 Oct 20;103:343-53. doi: 10.1016/j.ejmech.2015.08.056. Epub 2015 Sep 3. Eur J Med Chem. 2015. PMID: 26363870

5

Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.

Mao Q, Dai X, Xu G, Su Y, Zhang B, Liu D, Wang S. Mao Q, et al. Among authors: wang s. Eur J Med Chem. 2019 Nov 1;181:111558. doi: 10.1016/j.ejmech.2019.07.061. Epub 2019 Jul 23. Eur J Med Chem. 2019. PMID: 31369933

6

Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.

Zhang B, Dai X, Bao Z, Mao Q, Duan Y, Yang Y, Wang S. Zhang B, et al. Among authors: wang s. Eur J Med Chem. 2019 Nov 1;181:111559. doi: 10.1016/j.ejmech.2019.07.062. Epub 2019 Jul 24. Eur J Med Chem. 2019. PMID: 31376568

7

Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.

Gao J, Zhang Z, Zhang B, Mao Q, Dai X, Zou Q, Lei Y, Feng Y, Wang S. Gao J, et al. Among authors: wang s. Bioorg Chem. 2020 Jan;95:103564. doi: 10.1016/j.bioorg.2019.103564. Epub 2019 Dec 31. Bioorg Chem. 2020. PMID: 31927335

8

Design, synthesis and biological evaluation of 1-alkyl-5/6-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.

Gao J, Liu X, Zhang B, Mao Q, Zhang Z, Zou Q, Dai X, Wang S. Gao J, et al. Among authors: wang s. Eur J Med Chem. 2020 Mar 15;190:112077. doi: 10.1016/j.ejmech.2020.112077. Epub 2020 Jan 21. Eur J Med Chem. 2020. PMID: 32014678

9

Switching a Xanthine Oxidase Inhibitor to a Dual-Target Antagonist of P2Y₁ and P2Y₁₂ as an Oral Antiplatelet Agent with a Wider Therapeutic Window in Rats than Ticagrelor.

Lei Y, Zhang B, Liu D, Zhao J, Dai X, Gao J, Mao Q, Feng Y, Zhao J, Lin F, Duan Y, Zhang Y, Bao Z, Yang Y, Mou Y, Wang S. Lei Y, et al. Among authors: wang s. J Med Chem. 2020 Dec 24;63(24):15752-15772. doi: 10.1021/acs.jmedchem.0c01524. Epub 2020 Dec 12. J Med Chem. 2020. PMID: 33307675

10

Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site.

Sun M, Zhao J, Mao Q, Yan C, Zhang B, Yang Y, Dai X, Gao J, Lin F, Duan Y, Zhang T, Wang S. Sun M, et al. Among authors: wang s. Bioorg Med Chem. 2021 May 15;38:116117. doi: 10.1016/j.bmc.2021.116117. Epub 2021 Apr 2. Bioorg Med Chem. 2021. PMID: 33838610

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