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Profiling microRNA expression during senescence and aging: mining for a diagnostic tool of senescent-cell burden.
Weigl M, Krammer TL, Pultar M, Wieser M, Chaib S, Suda M, Diendorfer A, Khamina-Kotisch K, Giorgadze N, Pirtskhalava T, Johnson KO, Inman CL, Xue A, Lämmermann I, Meixner B, Wang L, Xu M, Grillari R, Ogrodnik M, Tchkonia T, Hackl M, Kirkland JL, Grillari J. Weigl M, et al. Among authors: kirkland jl. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588794. doi: 10.1101/2024.04.10.588794. bioRxiv. 2024. PMID: 38645053 Free PMC article. Preprint.
Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.
Casso-Chapa B, Vazquez González NA, Le NT, Palaskas NL, Nead KT, Eutsey LP, Samanthapudi VSK, Osborn AM, Lee J, Mejia G, Hoang O, Lin SH, Deswal A, Herrmann J, Wang G, Kirkland JL, Krishnan S, Wehrens XHT, Chini EN, Yusuf SW, Iliescu CA, Jain A, Burks JK, Seeley E, Lorenzi PL, Chau KM, Ostos Mendoza KC, Grumbach IM, Brookes PS, Hanssen NMJ, de Winther MPJ, Yvan-Charvet L, Kotla S, Schadler K, Abe JI. Casso-Chapa B, et al. Among authors: kirkland jl. Arterioscler Thromb Vasc Biol. 2025 Jan 16. doi: 10.1161/ATVBAHA.124.319870. Online ahead of print. Arterioscler Thromb Vasc Biol. 2025. PMID: 39817327 Review.
Stiffening symphony of aging: Biophysical changes in senescent osteocytes.
Tilton M, Weivoda M, Astudillo Potes M, Gingery A, Liu AY, Tchkonia T, Lu L, Kirkland JL. Tilton M, et al. Among authors: kirkland jl. Aging Cell. 2024 Dec;23(12):e14421. doi: 10.1111/acel.14421. Epub 2024 Nov 24. Aging Cell. 2024. PMID: 39582140 Free PMC article.
Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing.
Gasek NS, Yan P, Zhu J, Purushothaman KR, Kim T, Wang L, Wang B, Flynn WF, Sun M, Guo C, Huggins B, Sharafieh R, Zhou Y, Parizek V, Tchkonia T, Kirkland JL, Wyles SP, Xu M. Gasek NS, et al. Among authors: kirkland jl. Nat Aging. 2025 Jan;5(1):21-27. doi: 10.1038/s43587-024-00755-4. Epub 2024 Nov 13. Nat Aging. 2025. PMID: 39537987
Phenoconversion in Women and Men With Isolated REM Sleep Behavior Disorder: A Retrospective Cohort Study.
Alexandres CA, McCarter SJ, Tabatabai GM, LeClair-Visonneau L, Feemster JC, Gossard TR, Strainis EP, Jagielski JT, Kelleher MR, Finstuen T, Ali F, Botha H, Graff-Radford J, Olson EJ, Sandness DJ, Morgenthaler TJ, Kantarci K, Savica R, Singer W, Covassin N, Somers VK, Kirkland JL, Junna M, Lipford M, Matarese CA, Moore JL, Tippmann-Peikert M, Carvalho DZ, Boeve BF, Silber MH, St Louis EK. Alexandres CA, et al. Among authors: kirkland jl. Neurology. 2024 Nov 26;103(10):e209993. doi: 10.1212/WNL.0000000000209993. Epub 2024 Oct 25. Neurology. 2024. PMID: 39454123
The prompt to discover senolytics.
Kirkland JL. Kirkland JL. Nat Rev Mol Cell Biol. 2024 Dec;25(12):953. doi: 10.1038/s41580-024-00795-z. Nat Rev Mol Cell Biol. 2024. PMID: 39443756 No abstract available.
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial.
Silva M, Wacker DA, Driver BE, Staugaitis A, Niedernhofer LJ, Schmidt EL, Kirkland JL, Tchkonia T, Evans T, Serrano CH, Ventz S, Koopmeiners JS, Puskarich MA; STOP-Sepsis Investigators. Silva M, et al. Among authors: kirkland jl. Trials. 2024 Oct 21;25(1):698. doi: 10.1186/s13063-024-08474-2. Trials. 2024. PMID: 39434114 Free PMC article.
371 results