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Correction to "Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility".
Romero A, Ashcraft L, Chandra A, DiMassa V, Cremin P, Collibee SE, Chuang C, Hartman J, Hwee DT, St Jean D, Malinowski J, DeBenedetto M, Moebius DC, Payette J, Vargas R, Yeoman J, Motani A, Reagan J, Malik FI, Morgan BP. Romero A, et al. Among authors: vargas r. J Med Chem. 2025 Jan 9;68(1):850. doi: 10.1021/acs.jmedchem.4c02850. Epub 2024 Dec 26. J Med Chem. 2025. PMID: 39722587 Free PMC article. No abstract available.
Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility.
Romero A, Ashcraft L, Chandra A, DiMassa V, Cremin P, Collibee SE, Chuang C, Hartman J, Hwee DT, St Jean D, Malinowski J, DeBenedetto M, Moebius D, Payette J, Vargas R, Yeoman J, Motani A, Reagan J, Malik FI, Morgan BP. Romero A, et al. Among authors: vargas r. J Med Chem. 2024 May 23;67(10):7825-7835. doi: 10.1021/acs.jmedchem.3c02413. Epub 2024 May 10. J Med Chem. 2024. PMID: 38729623 Free PMC article.
Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
Lee KL, Ambler CM, Anderson DR, Boscoe BP, Bree AG, Brodfuehrer JI, Chang JS, Choi C, Chung S, Curran KJ, Day JE, Dehnhardt CM, Dower K, Drozda SE, Frisbie RK, Gavrin LK, Goldberg JA, Han S, Hegen M, Hepworth D, Hope HR, Kamtekar S, Kilty IC, Lee A, Lin LL, Lovering FE, Lowe MD, Mathias JP, Morgan HM, Murphy EA, Papaioannou N, Patny A, Pierce BS, Rao VR, Saiah E, Samardjiev IJ, Samas BM, Shen MWH, Shin JH, Soutter HH, Strohbach JW, Symanowicz PT, Thomason JR, Trzupek JD, Vargas R, Vincent F, Yan J, Zapf CW, Wright SW. Lee KL, et al. Among authors: vargas r. J Med Chem. 2017 Jul 13;60(13):5521-5542. doi: 10.1021/acs.jmedchem.7b00231. Epub 2017 Jun 14. J Med Chem. 2017. PMID: 28498658
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Lee KL, Behnke ML, Foley MA, Chen L, Wang W, Vargas R, Nunez J, Tam S, Mollova N, Xu X, Shen MW, Ramarao MK, Goodwin DG, Nickerson-Nutter CL, Abraham WM, Williams C, Clark JD, McKew JC. Lee KL, et al. Among authors: vargas r. Bioorg Med Chem. 2008 Feb 1;16(3):1345-58. doi: 10.1016/j.bmc.2007.10.060. Epub 2007 Oct 22. Bioorg Med Chem. 2008. PMID: 17998165
Molecular classification of endometrial cancers (EC) and association with relapse-free survival (RFS) and overall survival (OS) outcomes: Ancillary analysis of GOG-0258.
Clements A, Enserro D, Strickland KC, Previs R, Matei D, Mutch D, Powell M, Klopp A, Miller DS, Small W Jr, DiSilvestro P, Spirtos N, Cosgrove C, Sfakianos G, Liu JR, Vargas R, Shahin M, Corr B, Dessources K, Ueland F, Warshal D, Gillen J, Secord AA. Clements A, et al. Among authors: vargas r. Gynecol Oncol. 2025 Jan 23;193:119-129. doi: 10.1016/j.ygyno.2025.01.006. Online ahead of print. Gynecol Oncol. 2025. PMID: 39854806
Spatial resolution for forest carbon maps.
Duncanson L, Hunka N, Jucker T, Armston J, Harris N, Fatoyinbo L, Williams CA, Atkins JW, Raczka B, Serbin S, Keller M, Dubayah R, Babcock C, Cochrane MA, Hudak A, Hurtt GC, Montesano PM, Moskal LM, Park T, Saatchi S, Silva CA, Tang H, Vargas R, Weiskittel A, Wessels K, Goetz SJ. Duncanson L, et al. Among authors: vargas r. Science. 2025 Jan 24;387(6732):370-371. doi: 10.1126/science.adt6811. Epub 2025 Jan 23. Science. 2025. PMID: 39847632 No abstract available.
Distribution and bioconcentration of semivolatile organic compounds (SVOCs) in soils and vascular plant Colobanthus quitensis from Sub-Antarctic and Antarctic regions.
Egas C, Luarte T, Vargas R, Castro-Nallar E, Pozo K, Přibylová P, Martiník J, Molina-Montenegro M, Galbán-Malagón C. Egas C, et al. Among authors: vargas r. Sci Total Environ. 2025 Feb 1;963:178494. doi: 10.1016/j.scitotenv.2025.178494. Epub 2025 Jan 20. Sci Total Environ. 2025. PMID: 39827628
Dent disease: Clinical Practice Recommendations.
Bökenkamp A, Ariceta G, Böckenhauer D, Devuyst O, Emma F, van Bennekom D, Levtchenko E, Sayer J, Servais A, Vargas R, Zaniew M, Prikhodina L. Bökenkamp A, et al. Among authors: vargas r. Nephrol Dial Transplant. 2025 Jan 10:gfaf003. doi: 10.1093/ndt/gfaf003. Online ahead of print. Nephrol Dial Transplant. 2025. PMID: 39794284
821 results