Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin.
Morgan BP, Muci A, Lu PP, Qian X, Tochimoto T, Smith WW, Garard M, Kraynack E, Collibee S, Suehiro I, Tomasi A, Valdez SC, Wang W, Jiang H, Hartman J, Rodriguez HM, Kawas R, Sylvester S, Elias KA, Godinez G, Lee K, Anderson R, Sueoka S, Xu D, Wang Z, Djordjevic N, Malik FI, Morgans DJ Jr.
Morgan BP, et al.
ACS Med Chem Lett. 2010 Aug 20;1(9):472-7. doi: 10.1021/ml100138q. eCollection 2010 Dec 9.
ACS Med Chem Lett. 2010.
PMID: 24900233
Free PMC article.